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- W2298852992 endingPage "115" @default.
- W2298852992 startingPage "85" @default.
- W2298852992 abstract "Stem cells are a promising solution for the treatment of a variety of diseases. However, the limited survival and engraftment of transplanted cells due to a hostile ischemic environment is a bottleneck for effective utilization and commercialization. Within this environment, the majority of transplanted cells undergo apoptosis prior to participating in lineage differentiation and cellular integration. Therefore, in order to maximize the clinical utility of stem/progenitor cells, strategies must be employed to increase their adhesion, retention, and engraftment in vivo. Here, we reviewed key strategies that are being adopted to enhance the survival, retention, and engraftment of transplanted stem cells through the manipulation of both the stem cells and the surrounding environment. We describe how preconditioning of cells or cell manipulations strategies can enhance stem cell survival and engraftment after transplantation. We also discuss how biomaterials can enhance the function of stem cells for effective tissue regeneration. Biomaterials can incorporate or mimic extracellular function (ECM) function and enhance survival or differentiation of transplanted cells in vivo. Biomaterials can also promote angiogenesis, enhance engraftment and differentiation, and accelerate electromechanical integration of transplanted stem cells. Insight gained from this review may direct the development of future investigations and clinical trials." @default.
- W2298852992 created "2016-06-24" @default.
- W2298852992 creator A5053834597 @default.
- W2298852992 creator A5070668206 @default.
- W2298852992 creator A5084395399 @default.
- W2298852992 date "2016-06-01" @default.
- W2298852992 modified "2023-09-28" @default.
- W2298852992 title "Insight on stem cell preconditioning and instructive biomaterials to enhance cell adhesion, retention, and engraftment for tissue repair" @default.
- W2298852992 cites W1541080127 @default.
- W2298852992 cites W1557620842 @default.
- W2298852992 cites W1559528293 @default.
- W2298852992 cites W1568001924 @default.
- W2298852992 cites W1612744739 @default.
- W2298852992 cites W1781862077 @default.
- W2298852992 cites W1789002865 @default.
- W2298852992 cites W1898343554 @default.
- W2298852992 cites W1899356937 @default.
- W2298852992 cites W1899371747 @default.
- W2298852992 cites W1922292712 @default.
- W2298852992 cites W1964354605 @default.
- W2298852992 cites W1965380680 @default.
- W2298852992 cites W1967677292 @default.
- W2298852992 cites W1968811222 @default.
- W2298852992 cites W1968939951 @default.
- W2298852992 cites W1969095342 @default.
- W2298852992 cites W1969399504 @default.
- W2298852992 cites W1971727948 @default.
- W2298852992 cites W1972875347 @default.
- W2298852992 cites W1973424799 @default.
- W2298852992 cites W1974285372 @default.
- W2298852992 cites W1974432822 @default.
- W2298852992 cites W1974713567 @default.
- W2298852992 cites W1975633277 @default.
- W2298852992 cites W1976779973 @default.
- W2298852992 cites W1977600426 @default.
- W2298852992 cites W1977608305 @default.
- W2298852992 cites W1977934887 @default.
- W2298852992 cites W1977964721 @default.
- W2298852992 cites W1978063675 @default.
- W2298852992 cites W1980619689 @default.
- W2298852992 cites W1980939876 @default.
- W2298852992 cites W1980950023 @default.
- W2298852992 cites W1981481147 @default.
- W2298852992 cites W1982323513 @default.
- W2298852992 cites W1983451179 @default.
- W2298852992 cites W1983474398 @default.
- W2298852992 cites W1983675756 @default.
- W2298852992 cites W1985525878 @default.
- W2298852992 cites W1985731445 @default.
- W2298852992 cites W1986064724 @default.
- W2298852992 cites W1986543208 @default.
- W2298852992 cites W1987479692 @default.
- W2298852992 cites W1988188434 @default.
- W2298852992 cites W1988642487 @default.
- W2298852992 cites W1989500669 @default.
- W2298852992 cites W1989614658 @default.
- W2298852992 cites W1989910000 @default.
- W2298852992 cites W1990277219 @default.
- W2298852992 cites W1990313760 @default.
- W2298852992 cites W1991723371 @default.
- W2298852992 cites W1991889240 @default.
- W2298852992 cites W1991962824 @default.
- W2298852992 cites W1992074285 @default.
- W2298852992 cites W1992508009 @default.
- W2298852992 cites W1993680967 @default.
- W2298852992 cites W1993909108 @default.
- W2298852992 cites W1995153346 @default.
- W2298852992 cites W1997246078 @default.
- W2298852992 cites W1997721049 @default.
- W2298852992 cites W2000426718 @default.
- W2298852992 cites W2000920295 @default.
- W2298852992 cites W2003122418 @default.
- W2298852992 cites W2005266202 @default.
- W2298852992 cites W2005655057 @default.
- W2298852992 cites W2005911189 @default.
- W2298852992 cites W2007201869 @default.
- W2298852992 cites W2007842271 @default.
- W2298852992 cites W2007917647 @default.
- W2298852992 cites W2007965011 @default.
- W2298852992 cites W2009127599 @default.
- W2298852992 cites W2009327019 @default.
- W2298852992 cites W2009371945 @default.
- W2298852992 cites W2010121754 @default.
- W2298852992 cites W2010788195 @default.
- W2298852992 cites W2012549032 @default.
- W2298852992 cites W2013170875 @default.
- W2298852992 cites W2013825275 @default.
- W2298852992 cites W2014402245 @default.
- W2298852992 cites W2014505899 @default.
- W2298852992 cites W2014756661 @default.
- W2298852992 cites W2016297513 @default.
- W2298852992 cites W2016988339 @default.
- W2298852992 cites W2017068971 @default.
- W2298852992 cites W2018741703 @default.
- W2298852992 cites W2019680740 @default.
- W2298852992 cites W2020264229 @default.
- W2298852992 cites W2020410426 @default.
- W2298852992 cites W2021110745 @default.