Matches in SemOpenAlex for { <https://semopenalex.org/work/W2299013895> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2299013895 endingPage "76" @default.
- W2299013895 startingPage "69" @default.
- W2299013895 abstract "This study was undertaken to evaluate the long-term effect of a peripheral neuropathic pain model, chronic constriction injury (CCI) of the sciatic nerve, through analyses of electrophysiologic change, sciatic nerve function, and pain behavior.CCI of the sciatic nerve was induced in twelve rats as described by Bennett and Xie. Three parameters were monitored: spinal somatosensory evoked potential (SSEP) elicited by supramaximal stimulation of the posterior tibial nerve and recorded from the thoracolumbar junctional space; thermal hyperalgesia assessed by measuring paw withdrawal latency (PWL); and sciatic function index (SFI). All the values of these parameters were obtained before the CCI procedure (day 1 as a preoperative baseline, and again on days 5, 12, 19, 26, 33, 47, 61, 75, and 89). SSEP was also measured 3 hr after the CCI operation. Data were also obtained from contralateral limbs.All rats with CCI developed thermal hyperalgesia on day 5, as indicated by a significant reduction in PWL in the CCI limbs and a deterioration of the SFI compared with baseline values. These effects persisted to day 89. In the electrophysiologic study, 3 hrs after the CCI operation, the amplitude significantly decreased and latency significantly increased in all SSEP recordings. The changes persisted and showed no further statistically significant deterioration or recovery. The data demonstrated that the major electrophysiologic change after a constriction injury was the loss of conduction ability across the injury site in the fast-conducting fibers, but in the slow-conducting fibers the conduction ability was still preserved, which occurred immediately after the operation and persisted consistently for 89 days in the rats with behavior manifestations of neuropathic pain.Our findings suggest that SSEP is simple to obtain and sensitive in the acute phase of electrophysiological changes, but is limited for long-term evaluation after CCI." @default.
- W2299013895 created "2016-06-24" @default.
- W2299013895 creator A5005249092 @default.
- W2299013895 creator A5015635942 @default.
- W2299013895 creator A5042478885 @default.
- W2299013895 creator A5042681614 @default.
- W2299013895 creator A5049988467 @default.
- W2299013895 creator A5052967400 @default.
- W2299013895 creator A5071822245 @default.
- W2299013895 date "2004-06-01" @default.
- W2299013895 modified "2023-09-26" @default.
- W2299013895 title "A long-term analysis of the spinal somatosensory evoked potential of rats with sciatic constriction injury." @default.
- W2299013895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15346701" @default.
- W2299013895 hasPublicationYear "2004" @default.
- W2299013895 type Work @default.
- W2299013895 sameAs 2299013895 @default.
- W2299013895 citedByCount "0" @default.
- W2299013895 crossrefType "journal-article" @default.
- W2299013895 hasAuthorship W2299013895A5005249092 @default.
- W2299013895 hasAuthorship W2299013895A5015635942 @default.
- W2299013895 hasAuthorship W2299013895A5042478885 @default.
- W2299013895 hasAuthorship W2299013895A5042681614 @default.
- W2299013895 hasAuthorship W2299013895A5049988467 @default.
- W2299013895 hasAuthorship W2299013895A5052967400 @default.
- W2299013895 hasAuthorship W2299013895A5071822245 @default.
- W2299013895 hasConcept C118552586 @default.
- W2299013895 hasConcept C126322002 @default.
- W2299013895 hasConcept C15490471 @default.
- W2299013895 hasConcept C161941745 @default.
- W2299013895 hasConcept C164705383 @default.
- W2299013895 hasConcept C170493617 @default.
- W2299013895 hasConcept C172497186 @default.
- W2299013895 hasConcept C174940676 @default.
- W2299013895 hasConcept C185263204 @default.
- W2299013895 hasConcept C24998067 @default.
- W2299013895 hasConcept C2775991916 @default.
- W2299013895 hasConcept C2776588550 @default.
- W2299013895 hasConcept C2777107010 @default.
- W2299013895 hasConcept C2779245659 @default.
- W2299013895 hasConcept C2781149210 @default.
- W2299013895 hasConcept C42219234 @default.
- W2299013895 hasConcept C71924100 @default.
- W2299013895 hasConceptScore W2299013895C118552586 @default.
- W2299013895 hasConceptScore W2299013895C126322002 @default.
- W2299013895 hasConceptScore W2299013895C15490471 @default.
- W2299013895 hasConceptScore W2299013895C161941745 @default.
- W2299013895 hasConceptScore W2299013895C164705383 @default.
- W2299013895 hasConceptScore W2299013895C170493617 @default.
- W2299013895 hasConceptScore W2299013895C172497186 @default.
- W2299013895 hasConceptScore W2299013895C174940676 @default.
- W2299013895 hasConceptScore W2299013895C185263204 @default.
- W2299013895 hasConceptScore W2299013895C24998067 @default.
- W2299013895 hasConceptScore W2299013895C2775991916 @default.
- W2299013895 hasConceptScore W2299013895C2776588550 @default.
- W2299013895 hasConceptScore W2299013895C2777107010 @default.
- W2299013895 hasConceptScore W2299013895C2779245659 @default.
- W2299013895 hasConceptScore W2299013895C2781149210 @default.
- W2299013895 hasConceptScore W2299013895C42219234 @default.
- W2299013895 hasConceptScore W2299013895C71924100 @default.
- W2299013895 hasIssue "2" @default.
- W2299013895 hasLocation W22990138951 @default.
- W2299013895 hasOpenAccess W2299013895 @default.
- W2299013895 hasPrimaryLocation W22990138951 @default.
- W2299013895 hasRelatedWork W1991354073 @default.
- W2299013895 hasRelatedWork W2006274944 @default.
- W2299013895 hasRelatedWork W2012407109 @default.
- W2299013895 hasRelatedWork W2020709826 @default.
- W2299013895 hasRelatedWork W2023771303 @default.
- W2299013895 hasRelatedWork W2051707742 @default.
- W2299013895 hasRelatedWork W2076499441 @default.
- W2299013895 hasRelatedWork W2079692119 @default.
- W2299013895 hasRelatedWork W2119577692 @default.
- W2299013895 hasRelatedWork W2141173907 @default.
- W2299013895 hasRelatedWork W2331659843 @default.
- W2299013895 hasRelatedWork W2353004537 @default.
- W2299013895 hasRelatedWork W2356273870 @default.
- W2299013895 hasRelatedWork W2377760027 @default.
- W2299013895 hasRelatedWork W2440218602 @default.
- W2299013895 hasRelatedWork W2778763555 @default.
- W2299013895 hasRelatedWork W2915274456 @default.
- W2299013895 hasRelatedWork W3031850673 @default.
- W2299013895 hasRelatedWork W3081508393 @default.
- W2299013895 hasRelatedWork W2904306678 @default.
- W2299013895 hasVolume "42" @default.
- W2299013895 isParatext "false" @default.
- W2299013895 isRetracted "false" @default.
- W2299013895 magId "2299013895" @default.
- W2299013895 workType "article" @default.