Matches in SemOpenAlex for { <https://semopenalex.org/work/W2299029899> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2299029899 startingPage "2800" @default.
- W2299029899 abstract "To date, the treatment outcome of non small cell lung cancer (NSCLC) is still not satisfactory and new treatment options are urgently needed. The present study was designed to: 1) evaluate the effects of the antiangiogenic drug; nimesulide (NSAID, a COX-2 inhibitor) combined with chemotherapy on NSCLC treatment progress, 2) Evaluate the role of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), as prognostic indicators in NSCLC, 3) Correlate the above parameters levels with the clinicopathological status of the patients during the therapy. The study included 30 NSCLC.Methods: The patients were divided to: group I, included 17 patients received chemotherapy alone and group II included 13 patients received the same chemotherapy with Nimesulide and 10 as controls. Serum and biopsies were taken for all subjects on admission and 3 weeks after the completion of treatment.Results: Serum and tissue levels of VEGF and bFGF, were significantly higher in NSCLC patients and decreased significantly after treatment specially in group II compared to group I. The serum and tissue levels of the studied parameters decreased significantly in the responders as compared to resistant cases. The response rate after combined therapy was 69% versus 53% after chemotherapy alone.Conclusion: In conclusion, Nimesulide appears to boost the efficacy of the traditional chemotherapy as its co-administration showed encouraging effects on improving and normalization of the proangiogenic parameters levels and in turn the vascular supply of tumors. This may have good impact on the patient outcome, prolongation of their survival rate and prognosis." @default.
- W2299029899 created "2016-06-24" @default.
- W2299029899 creator A5015568177 @default.
- W2299029899 creator A5016244243 @default.
- W2299029899 creator A5020694489 @default.
- W2299029899 creator A5078247284 @default.
- W2299029899 date "2011-09-01" @default.
- W2299029899 modified "2023-09-27" @default.
- W2299029899 title "Emerging prognostic biomarkers in non small cell lung cancer patients: Impact of treatment with nimesulide (COX-2 inhibitor) combined with chemotherapy" @default.
- W2299029899 hasPublicationYear "2011" @default.
- W2299029899 type Work @default.
- W2299029899 sameAs 2299029899 @default.
- W2299029899 citedByCount "1" @default.
- W2299029899 countsByYear W22990298992014 @default.
- W2299029899 crossrefType "journal-article" @default.
- W2299029899 hasAuthorship W2299029899A5015568177 @default.
- W2299029899 hasAuthorship W2299029899A5016244243 @default.
- W2299029899 hasAuthorship W2299029899A5020694489 @default.
- W2299029899 hasAuthorship W2299029899A5078247284 @default.
- W2299029899 hasConcept C126322002 @default.
- W2299029899 hasConcept C143998085 @default.
- W2299029899 hasConcept C167734588 @default.
- W2299029899 hasConcept C170493617 @default.
- W2299029899 hasConcept C2775960820 @default.
- W2299029899 hasConcept C2776256026 @default.
- W2299029899 hasConcept C2776694085 @default.
- W2299029899 hasConcept C2777025900 @default.
- W2299029899 hasConcept C2777570176 @default.
- W2299029899 hasConcept C2777587049 @default.
- W2299029899 hasConcept C71924100 @default.
- W2299029899 hasConcept C90924648 @default.
- W2299029899 hasConceptScore W2299029899C126322002 @default.
- W2299029899 hasConceptScore W2299029899C143998085 @default.
- W2299029899 hasConceptScore W2299029899C167734588 @default.
- W2299029899 hasConceptScore W2299029899C170493617 @default.
- W2299029899 hasConceptScore W2299029899C2775960820 @default.
- W2299029899 hasConceptScore W2299029899C2776256026 @default.
- W2299029899 hasConceptScore W2299029899C2776694085 @default.
- W2299029899 hasConceptScore W2299029899C2777025900 @default.
- W2299029899 hasConceptScore W2299029899C2777570176 @default.
- W2299029899 hasConceptScore W2299029899C2777587049 @default.
- W2299029899 hasConceptScore W2299029899C71924100 @default.
- W2299029899 hasConceptScore W2299029899C90924648 @default.
- W2299029899 hasLocation W22990298991 @default.
- W2299029899 hasOpenAccess W2299029899 @default.
- W2299029899 hasPrimaryLocation W22990298991 @default.
- W2299029899 hasRelatedWork W2053258375 @default.
- W2299029899 hasRelatedWork W2079203759 @default.
- W2299029899 hasRelatedWork W2119212455 @default.
- W2299029899 hasRelatedWork W2352535670 @default.
- W2299029899 hasRelatedWork W2354977923 @default.
- W2299029899 hasRelatedWork W2355640768 @default.
- W2299029899 hasRelatedWork W2367619230 @default.
- W2299029899 hasRelatedWork W2418580641 @default.
- W2299029899 hasRelatedWork W2435963675 @default.
- W2299029899 hasRelatedWork W2625278111 @default.
- W2299029899 hasRelatedWork W2743001405 @default.
- W2299029899 hasRelatedWork W2801104802 @default.
- W2299029899 hasRelatedWork W2803550773 @default.
- W2299029899 hasRelatedWork W289936159 @default.
- W2299029899 hasRelatedWork W2947823179 @default.
- W2299029899 hasRelatedWork W3009687810 @default.
- W2299029899 hasRelatedWork W3033725900 @default.
- W2299029899 hasRelatedWork W3038900609 @default.
- W2299029899 hasRelatedWork W3185014099 @default.
- W2299029899 hasRelatedWork W3196348907 @default.
- W2299029899 hasVolume "38" @default.
- W2299029899 isParatext "false" @default.
- W2299029899 isRetracted "false" @default.
- W2299029899 magId "2299029899" @default.
- W2299029899 workType "article" @default.