Matches in SemOpenAlex for { <https://semopenalex.org/work/W2299048545> ?p ?o ?g. }
- W2299048545 endingPage "43" @default.
- W2299048545 startingPage "1134" @default.
- W2299048545 abstract "Pathways of metabolism of dichloroacetate (DCA), an investigational drug for the treatment of lactic acidosis in humans and a rodent hepatocarcinogen, are poorly understood. In this study, rats were given, by gavage, one or two 50 mg/kg doses of NaDCA. DCA labeled with 14C (carboxy carbon) or 13C (both carbons) was used in studies of disposition and pharmacokinetics, respectively. The effect of fasting for 14 hr before dosing was studied. Expired air, urine, feces, and tissues were collected from [14C]DCA-dosed rats. Urine was analyzed by HPLC, GC/MS, and NMR spectroscopy. Plasma samples were analyzed by GC/MS. DCA plasma elimination half-lives were 0.1 +/- 0.02 and 5.4 +/- 0.8 hr in young adult rats (180-265 g, 3-4 months of age) given one or two doses of DCA, respectively, and 9.7 +/- 1 hr in large, 16-month-old rats given two DCA doses. The percentage of the DCA dose excreted as CO2 varied from 17 to 46% and was lower (p < 0.001) in fed rats, compared with rats fasted overnight before dosing. Urine contained DCA and DCA metabolites, including oxalate, glyoxylate, and conjugated glycine (mainly hippurate and phenylacetylglycine). More unchanged DCA was excreted by large rats pretreated with DCA (mean, 20.2% of the dose) than by young adult rats given one dose of DCA (mean, 0.5%). This study confirmed that CO2, glycine, and oxalate are major products of DCA metabolism, it demonstrated that one dose of DCA altered the elimination of a subsequent dose, and it showed that age or body size, as well as access to food, significantly affected DCA metabolism in rats." @default.
- W2299048545 created "2016-06-24" @default.
- W2299048545 creator A5007253402 @default.
- W2299048545 creator A5016593841 @default.
- W2299048545 creator A5025673321 @default.
- W2299048545 creator A5047743553 @default.
- W2299048545 creator A5060966927 @default.
- W2299048545 creator A5071914558 @default.
- W2299048545 creator A5080489320 @default.
- W2299048545 creator A5091287512 @default.
- W2299048545 creator A5091880488 @default.
- W2299048545 date "1998-11-01" @default.
- W2299048545 modified "2023-10-17" @default.
- W2299048545 title "Pharmacokinetics and metabolism of [14C]dichloroacetate in male Sprague-Dawley rats. Identification of glycine conjugates, including hippurate, as urinary metabolites of dichloroacetate." @default.
- W2299048545 cites W145522988 @default.
- W2299048545 cites W1530639715 @default.
- W2299048545 cites W1829871098 @default.
- W2299048545 cites W1901297582 @default.
- W2299048545 cites W1919124023 @default.
- W2299048545 cites W1936428419 @default.
- W2299048545 cites W1969302343 @default.
- W2299048545 cites W1981469547 @default.
- W2299048545 cites W1982971466 @default.
- W2299048545 cites W1991908530 @default.
- W2299048545 cites W1994148625 @default.
- W2299048545 cites W1994269797 @default.
- W2299048545 cites W1998211590 @default.
- W2299048545 cites W2007015999 @default.
- W2299048545 cites W2010439424 @default.
- W2299048545 cites W2022939397 @default.
- W2299048545 cites W2033725686 @default.
- W2299048545 cites W2040823633 @default.
- W2299048545 cites W2046600124 @default.
- W2299048545 cites W2053087179 @default.
- W2299048545 cites W2058860879 @default.
- W2299048545 cites W2060123593 @default.
- W2299048545 cites W2069205839 @default.
- W2299048545 cites W2070936851 @default.
- W2299048545 cites W2073854137 @default.
- W2299048545 cites W2076750233 @default.
- W2299048545 cites W2078871999 @default.
- W2299048545 cites W2079032076 @default.
- W2299048545 cites W2082100392 @default.
- W2299048545 cites W2082160888 @default.
- W2299048545 cites W2093327304 @default.
- W2299048545 cites W2105399208 @default.
- W2299048545 cites W2146788158 @default.
- W2299048545 cites W2305627972 @default.
- W2299048545 cites W2396642158 @default.
- W2299048545 cites W2416099046 @default.
- W2299048545 cites W275717257 @default.
- W2299048545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9806957" @default.
- W2299048545 hasPublicationYear "1998" @default.
- W2299048545 type Work @default.
- W2299048545 sameAs 2299048545 @default.
- W2299048545 citedByCount "14" @default.
- W2299048545 countsByYear W22990485452012 @default.
- W2299048545 countsByYear W22990485452014 @default.
- W2299048545 countsByYear W22990485452016 @default.
- W2299048545 countsByYear W22990485452017 @default.
- W2299048545 countsByYear W22990485452018 @default.
- W2299048545 countsByYear W22990485452019 @default.
- W2299048545 crossrefType "journal-article" @default.
- W2299048545 hasAuthorship W2299048545A5007253402 @default.
- W2299048545 hasAuthorship W2299048545A5016593841 @default.
- W2299048545 hasAuthorship W2299048545A5025673321 @default.
- W2299048545 hasAuthorship W2299048545A5047743553 @default.
- W2299048545 hasAuthorship W2299048545A5060966927 @default.
- W2299048545 hasAuthorship W2299048545A5071914558 @default.
- W2299048545 hasAuthorship W2299048545A5080489320 @default.
- W2299048545 hasAuthorship W2299048545A5091287512 @default.
- W2299048545 hasAuthorship W2299048545A5091880488 @default.
- W2299048545 hasConcept C112705442 @default.
- W2299048545 hasConcept C126322002 @default.
- W2299048545 hasConcept C134018914 @default.
- W2299048545 hasConcept C178790620 @default.
- W2299048545 hasConcept C185592680 @default.
- W2299048545 hasConcept C2776351790 @default.
- W2299048545 hasConcept C2777477808 @default.
- W2299048545 hasConcept C2777616060 @default.
- W2299048545 hasConcept C2777756961 @default.
- W2299048545 hasConcept C2780026642 @default.
- W2299048545 hasConcept C515207424 @default.
- W2299048545 hasConcept C55493867 @default.
- W2299048545 hasConcept C62231903 @default.
- W2299048545 hasConcept C71924100 @default.
- W2299048545 hasConcept C98274493 @default.
- W2299048545 hasConceptScore W2299048545C112705442 @default.
- W2299048545 hasConceptScore W2299048545C126322002 @default.
- W2299048545 hasConceptScore W2299048545C134018914 @default.
- W2299048545 hasConceptScore W2299048545C178790620 @default.
- W2299048545 hasConceptScore W2299048545C185592680 @default.
- W2299048545 hasConceptScore W2299048545C2776351790 @default.
- W2299048545 hasConceptScore W2299048545C2777477808 @default.
- W2299048545 hasConceptScore W2299048545C2777616060 @default.
- W2299048545 hasConceptScore W2299048545C2777756961 @default.
- W2299048545 hasConceptScore W2299048545C2780026642 @default.
- W2299048545 hasConceptScore W2299048545C515207424 @default.