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- W2299054370 abstract "We derive a sophisticated mathematical model for coupled heat and mass transport in the tumour microenvironment and we apply it to study nanoparticle delivery and hyperthermic treatment of cancer. The model has the unique ability of combining the following features: (i) realistic vasculature; (ii) coupled capillary and interstitial flow; (iii) coupled capillary and interstitial mass transfer applied to nanoparticles; and (iv) coupled capillary and interstitial heat transfer, which are the fundamental mechanisms governing nano-based hyperthermic treatment. This is an improvement with respect to previous modelling approaches, where the effect of blood perfusion on heat transfer is modelled in a spatially averaged form. We analyse the time evolution and the spatial distribution of particles and temperature in a tumour mass treated with superparamagnetic nanoparticles excited by an alternating magnetic field. By means of numerical experiments, we synthesize scaling laws that illustrate how nano-based hyperthermia depends on tumour size and vascularity. In particular, we identify two distinct mechanisms that regulate the distribution of particle and temperature, which are characterized by perfusion and diffusion, respectively." @default.
- W2299054370 created "2016-06-24" @default.
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- W2299054370 creator A5061631250 @default.
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- W2299054370 date "2015-10-01" @default.
- W2299054370 modified "2023-09-23" @default.
- W2299054370 title "Modelling mass and heat transfer in nano-based cancer hyperthermia" @default.
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- W2299054370 doi "https://doi.org/10.1098/rsos.150447" @default.
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