Matches in SemOpenAlex for { <https://semopenalex.org/work/W2299106222> ?p ?o ?g. }
- W2299106222 endingPage "39" @default.
- W2299106222 startingPage "31" @default.
- W2299106222 abstract "Chronic oral treatment of tetrabromobisphenol A (TBBPA) to female Wistar Han rats resulted in increased incidence of cell proliferation at 250 mg/kg and tumor formation in the uterus at higher doses. The present study was designed to test the hypothesis that disruption of estrogen homeostasis was a major mode-of-action for the observed effects. Biological changes were assessed in serum, liver, and the proximal (nearest the cervix) and distal (nearest the ovaries) sections of the uterine horn of Wistar Han rats 24 h following administration of the last of five daily oral doses of 250 mg/kg. Expression of genes associated with receptors, biosynthesis, and metabolism of estrogen was altered in the liver and uterus. TBBPA treatment also resulted in changes in expression of genes associated with cell division and growth. Changes were also observed in the concentration of thyroxine in serum and in expression of genes in the liver and uterus associated with thyroid hormone receptors. Differential expression of some genes was tissue-dependent or specific to tissue location in the uterus. The biological responses observed in the present study support the hypothesis that perturbation of estrogen homeostasis is a major mode-of-action for TBBPA-mediated cell proliferation and tumorigenesis previously observed in the uterus of TBBPA-treated Wistar Han rats." @default.
- W2299106222 created "2016-06-24" @default.
- W2299106222 creator A5001329019 @default.
- W2299106222 creator A5001941341 @default.
- W2299106222 creator A5008208415 @default.
- W2299106222 creator A5023792841 @default.
- W2299106222 creator A5045523281 @default.
- W2299106222 creator A5065650387 @default.
- W2299106222 date "2016-05-01" @default.
- W2299106222 modified "2023-09-25" @default.
- W2299106222 title "Disruption of estrogen homeostasis as a mechanism for uterine toxicity in Wistar Han rats treated with tetrabromobisphenol A" @default.
- W2299106222 cites W1511253153 @default.
- W2299106222 cites W1527874837 @default.
- W2299106222 cites W1577577364 @default.
- W2299106222 cites W1831171968 @default.
- W2299106222 cites W1964247465 @default.
- W2299106222 cites W1970449952 @default.
- W2299106222 cites W1971662309 @default.
- W2299106222 cites W1981268203 @default.
- W2299106222 cites W1984401164 @default.
- W2299106222 cites W1994057271 @default.
- W2299106222 cites W2013626486 @default.
- W2299106222 cites W2017276221 @default.
- W2299106222 cites W2026313373 @default.
- W2299106222 cites W2035835146 @default.
- W2299106222 cites W2037816886 @default.
- W2299106222 cites W2041680723 @default.
- W2299106222 cites W2043141560 @default.
- W2299106222 cites W2044603199 @default.
- W2299106222 cites W2045071977 @default.
- W2299106222 cites W2056530995 @default.
- W2299106222 cites W2062753439 @default.
- W2299106222 cites W2065528753 @default.
- W2299106222 cites W2069625934 @default.
- W2299106222 cites W2070443422 @default.
- W2299106222 cites W2100492886 @default.
- W2299106222 cites W2101298518 @default.
- W2299106222 cites W2109561093 @default.
- W2299106222 cites W2118342319 @default.
- W2299106222 cites W2118925298 @default.
- W2299106222 cites W2128676243 @default.
- W2299106222 cites W2128905231 @default.
- W2299106222 cites W2132024398 @default.
- W2299106222 cites W2142107163 @default.
- W2299106222 cites W2152739011 @default.
- W2299106222 cites W2156998465 @default.
- W2299106222 cites W2159937320 @default.
- W2299106222 cites W2161817637 @default.
- W2299106222 cites W2162678089 @default.
- W2299106222 cites W2168251468 @default.
- W2299106222 cites W2168481287 @default.
- W2299106222 cites W2227122201 @default.
- W2299106222 cites W2340959679 @default.
- W2299106222 cites W2417188134 @default.
- W2299106222 cites W2614170766 @default.
- W2299106222 doi "https://doi.org/10.1016/j.taap.2016.03.007" @default.
- W2299106222 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4825186" @default.
- W2299106222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26988606" @default.
- W2299106222 hasPublicationYear "2016" @default.
- W2299106222 type Work @default.
- W2299106222 sameAs 2299106222 @default.
- W2299106222 citedByCount "28" @default.
- W2299106222 countsByYear W22991062222015 @default.
- W2299106222 countsByYear W22991062222016 @default.
- W2299106222 countsByYear W22991062222017 @default.
- W2299106222 countsByYear W22991062222018 @default.
- W2299106222 countsByYear W22991062222019 @default.
- W2299106222 countsByYear W22991062222020 @default.
- W2299106222 countsByYear W22991062222021 @default.
- W2299106222 countsByYear W22991062222022 @default.
- W2299106222 countsByYear W22991062222023 @default.
- W2299106222 crossrefType "journal-article" @default.
- W2299106222 hasAuthorship W2299106222A5001329019 @default.
- W2299106222 hasAuthorship W2299106222A5001941341 @default.
- W2299106222 hasAuthorship W2299106222A5008208415 @default.
- W2299106222 hasAuthorship W2299106222A5023792841 @default.
- W2299106222 hasAuthorship W2299106222A5045523281 @default.
- W2299106222 hasAuthorship W2299106222A5065650387 @default.
- W2299106222 hasBestOaLocation W22991062222 @default.
- W2299106222 hasConcept C121608353 @default.
- W2299106222 hasConcept C126322002 @default.
- W2299106222 hasConcept C134018914 @default.
- W2299106222 hasConcept C170493617 @default.
- W2299106222 hasConcept C178790620 @default.
- W2299106222 hasConcept C185592680 @default.
- W2299106222 hasConcept C205474432 @default.
- W2299106222 hasConcept C2777164284 @default.
- W2299106222 hasConcept C2779066055 @default.
- W2299106222 hasConcept C2780287514 @default.
- W2299106222 hasConcept C29730261 @default.
- W2299106222 hasConcept C530470458 @default.
- W2299106222 hasConcept C54355233 @default.
- W2299106222 hasConcept C62112901 @default.
- W2299106222 hasConcept C63645605 @default.
- W2299106222 hasConcept C71924100 @default.
- W2299106222 hasConcept C84606932 @default.
- W2299106222 hasConcept C86803240 @default.
- W2299106222 hasConceptScore W2299106222C121608353 @default.