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- W2299176614 abstract "Background: The purpose of this study was to evaluate the effect of DM-BSF treatment for 6 months on bone mineral density (BMD) in postmenopausal women. Methods: This was a 24-week parallel-group, double-blind, randomized, placebo-controlled trial consisting of 5 visits. A total of 20 participants were randomized to either DM-BSF (n = 10) group or the placebo group (n = 10). Subjects were administered with a capsule of DM-BSF or placebo 3 times a day. BMD, bone-specific alkaline phosphatase (BSAP), serum C-telopeptide of collagen cross-links (CTx), and insulin-like growth factor-1 (IGF-1) were measured at baseline (visit 2) and at 24-week (visit 5). Results: A total of 20 women were included in this study (mean ± standard deviation [SD] age, 57.7 ± 2.68 years; mean ± SD lumbar spine BMD T-score, -1.91 ± 0.95; mean ± SD right femur BMD T-score, -1.89 ± 0.74; DM-BSF group, N = 10; placebo group, N = 10). In the DM-BSF group, the mean percentage change of the total T-score of the right femur after 24 weeks compared to the baseline period increased by 0.01 ± 0.11, as opposed to the placebo group, whose mean percentage change decreased by 0.12 ± 0.10 (P = 0.0110). No statistically significant difference was observed between the DM-BSF group and the placebo group with regard to the mean percentage change of BSAP, serum CTx, and IGF-1 at week 24 (visit 5) compared to the baseline period (visit 2). No adverse events were reported in either group. Conclusion: DM-BSF was well tolerated and had significant beneficial effects on local bone mineral density in postmenopausal women. In these postmenopausal women, 24-week treatment with 3 DM-BSF capsules a day was associated with the potential prevention of bone loss at the hip (based on a significant increase in BMD in the femur)." @default.
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- W2299176614 date "2015-12-30" @default.
- W2299176614 modified "2023-09-29" @default.
- W2299176614 title "Effect of DM-BSF on Bone Mineral Density in Postmenopausal Women: Randomized, Double- Blind, Placebo-Controlled, Parallel Trial" @default.
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