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- W2299348045 abstract "Acute coronary syndromes are a leading cause of mortality and morbidity in the UK. The underlying pathology is rupture or fissure of a coronary atherosclerotic plaque, which leads to thrombus formation. This results in a restriction or occlusion of coronary blood flow and the resultant presentation of an acute coronary syndrome. Platelets play a pivotal role in this pathophysiological process and are the focus of pharmacological therapy. Ticagrelor is an anti-platelet agent that inhibits the activation of the glycoprotein IIb/IIIa receptors on the platelet and therefore prevents platelet aggregation and thrombus formation. The PLATelet inhibition and patient Outcomes Trial (Wallentin et al, 2009) demonstrated superiority over clopidogrel in the reduction of major adverse cardiovascular events, including mortality. Common adverse effects include bleeding, dyspnoea and ventricular pauses. Maintenance dosing involves twice-daily administration, which poses a risk of noncompliance. Patient education is essent..." @default.
- W2299348045 created "2016-06-24" @default.
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- W2299348045 date "2016-03-02" @default.
- W2299348045 modified "2023-09-27" @default.
- W2299348045 title "Prescribing ticagrelor to treat acute coronary syndromes" @default.
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- W2299348045 doi "https://doi.org/10.12968/npre.2016.14.3.132" @default.
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