FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2299517286> ?p ?o ?g. }

• W2299517286 endingPage "729" @default.
• W2299517286 startingPage "729" @default.
• W2299517286 abstract "Purpose: Natural products have been a great source of medications used in conventional medicines for the treatment of various diseases; more importantly, they have played a significant role in the development of anti-cancer drugs for a number of decades. The benefits to employing whole extracts of natural health products, rather than a single ingredient, for cancer treatment remains unexplored. Our research group has previously demonstrated the potential anti-cancer benefits of several natural health products (NHPs), prompting further studies into other NHPs, such as Neem (Azadarichta indica), a tree native to India and has been used in Ayurvedic medicine for over 4000 years. The objective of this study is to determine the possible anti-cancer potential of aqueous and ethanolic Neem leaf extracts (NLEs) and to identify the specific mode(s) of action. Methods: Cells were treated with NLE and cell viability was then assessed using a water-soluble tetrazolium salt. Cell death was confirmed using the fluorescent dye propidium iodide and apoptosis was identified using the Annexin-V binding assay. Mitochondrial membrane permeabilization was visualized using JC-1 staining and the production of whole cell and mitochondrial ROS was measured with 2’,7’-dichlorodihydrofluorescein diacetate (H2DCFDA) and Amplex Red, respectively. In vivo efficacy of aqueous NLE was assessed in human tumour xenografts in CD-1 nu/nu immunocompromised mice. Results: Results indicate that both ethanolic and aqueous extracts of Neem leaf were effective in inducing apoptosis in leukemia and colon cancer cells, following destabilization of the mitochondrial membrane. Furthermore, an increase in the production of reactive oxygen species (ROS) was observed in cancer cells treated with NLEs, indicating that oxidative stress may play a role in the mechanism of cell death. Additionally, in vivo results showed that aqueous NLE (delivered orally) was well tolerated and inhibited tumour growth of human xenografts in mice. Conclusions: These findings suggest the potential of NLEs as safer and effective alternatives to conventional chemotherapy. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page." @default.
• W2299517286 created "2016-06-24" @default.
• W2299517286 creator A5028506682 @default.
• W2299517286 creator A5069207187 @default.
• W2299517286 creator A5070689899 @default.
• W2299517286 creator A5072528667 @default.
• W2299517286 creator A5085535503 @default.
• W2299517286 creator A5087467910 @default.
• W2299517286 date "2015-11-13" @default.
• W2299517286 modified "2023-10-11" @default.
• W2299517286 title "Selective Induction of Apoptosis by Azadarichta indica Leaf Extract by Targeting Oxidative Vulnerabilities in Human Cancer Cells" @default.
• W2299517286 cites W1977178308 @default.
• W2299517286 cites W1980991800 @default.
• W2299517286 cites W2010023860 @default.
• W2299517286 cites W2028300044 @default.
• W2299517286 cites W2034269086 @default.
• W2299517286 cites W2055194666 @default.
• W2299517286 cites W2072952401 @default.
• W2299517286 cites W2074305443 @default.
• W2299517286 cites W2075096138 @default.
• W2299517286 cites W2090492168 @default.
• W2299517286 cites W2099408190 @default.
• W2299517286 cites W2117696416 @default.
• W2299517286 cites W2129778797 @default.
• W2299517286 cites W2132820976 @default.
• W2299517286 cites W2148125367 @default.
• W2299517286 cites W2153659956 @default.
• W2299517286 cites W227829529 @default.
• W2299517286 cites W60652660 @default.
• W2299517286 doi "https://doi.org/10.18433/j3vg76" @default.
• W2299517286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26626256" @default.
• W2299517286 hasPublicationYear "2015" @default.
• W2299517286 type Work @default.
• W2299517286 sameAs 2299517286 @default.
• W2299517286 citedByCount "9" @default.
• W2299517286 countsByYear W22995172862016 @default.
• W2299517286 countsByYear W22995172862017 @default.
• W2299517286 countsByYear W22995172862020 @default.
• W2299517286 countsByYear W22995172862021 @default.
• W2299517286 countsByYear W22995172862022 @default.
• W2299517286 countsByYear W22995172862023 @default.
• W2299517286 crossrefType "journal-article" @default.
• W2299517286 hasAuthorship W2299517286A5028506682 @default.
• W2299517286 hasAuthorship W2299517286A5069207187 @default.
• W2299517286 hasAuthorship W2299517286A5070689899 @default.
• W2299517286 hasAuthorship W2299517286A5072528667 @default.
• W2299517286 hasAuthorship W2299517286A5085535503 @default.
• W2299517286 hasAuthorship W2299517286A5087467910 @default.
• W2299517286 hasBestOaLocation W22995172861 @default.
• W2299517286 hasConcept C121608353 @default.
• W2299517286 hasConcept C150903083 @default.
• W2299517286 hasConcept C185592680 @default.
• W2299517286 hasConcept C190283241 @default.
• W2299517286 hasConcept C207001950 @default.
• W2299517286 hasConcept C2775934118 @default.
• W2299517286 hasConcept C31573885 @default.
• W2299517286 hasConcept C53227056 @default.
• W2299517286 hasConcept C54355233 @default.
• W2299517286 hasConcept C55493867 @default.
• W2299517286 hasConcept C556039675 @default.
• W2299517286 hasConcept C71924100 @default.
• W2299517286 hasConcept C86803240 @default.
• W2299517286 hasConcept C88634738 @default.
• W2299517286 hasConcept C96232424 @default.
• W2299517286 hasConcept C98274493 @default.
• W2299517286 hasConceptScore W2299517286C121608353 @default.
• W2299517286 hasConceptScore W2299517286C150903083 @default.
• W2299517286 hasConceptScore W2299517286C185592680 @default.
• W2299517286 hasConceptScore W2299517286C190283241 @default.
• W2299517286 hasConceptScore W2299517286C207001950 @default.
• W2299517286 hasConceptScore W2299517286C2775934118 @default.
• W2299517286 hasConceptScore W2299517286C31573885 @default.
• W2299517286 hasConceptScore W2299517286C53227056 @default.
• W2299517286 hasConceptScore W2299517286C54355233 @default.
• W2299517286 hasConceptScore W2299517286C55493867 @default.
• W2299517286 hasConceptScore W2299517286C556039675 @default.
• W2299517286 hasConceptScore W2299517286C71924100 @default.
• W2299517286 hasConceptScore W2299517286C86803240 @default.
• W2299517286 hasConceptScore W2299517286C88634738 @default.
• W2299517286 hasConceptScore W2299517286C96232424 @default.
• W2299517286 hasConceptScore W2299517286C98274493 @default.
• W2299517286 hasIssue "4" @default.
• W2299517286 hasLocation W22995172861 @default.
• W2299517286 hasLocation W22995172862 @default.
• W2299517286 hasOpenAccess W2299517286 @default.
• W2299517286 hasPrimaryLocation W22995172861 @default.
• W2299517286 hasRelatedWork W1935661054 @default.
• W2299517286 hasRelatedWork W1974119714 @default.
• W2299517286 hasRelatedWork W2044152887 @default.
• W2299517286 hasRelatedWork W2184277213 @default.
• W2299517286 hasRelatedWork W2365320098 @default.
• W2299517286 hasRelatedWork W2375889511 @default.
• W2299517286 hasRelatedWork W2393858372 @default.
• W2299517286 hasRelatedWork W2548469661 @default.
• W2299517286 hasRelatedWork W3135269592 @default.
• W2299517286 hasRelatedWork W4385687789 @default.
• W2299517286 hasVolume "18" @default.
• W2299517286 isParatext "false" @default.

• next