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- W2299520011 abstract "Colloidal ultrasmall superparamagnetic iron oxide nanoparticles (USNPs) with better control of their surface chemistry have been considered as a biocompatible alternative to clinically used gadolinium-based contrast agents for in vivo bright magnetic resonance imaging (MRI). Herein, we report a versatile mussel-inspired multidentate block copolymer strategy that allows for the stabilization of USNPs as promising MRI contrast agents with excellent colloidal stability. A well-controlled multidentate block copolymer with pendant multiple catechol groups (Cat-MDBC) is synthesized by a combination of controlled radical polymerization and postmodification methods. The Cat-MDBC proves to be effective to strongly anchor to USNP surfaces as well as provide optimal hydrophilic surfaces, thus enabling the fabrication of aqueous Cat-MDBC/USNP colloids at single layers with a diameter of ≈20 nm through a biphasic ligand exchange process. They exhibit excellent colloidal stability in broad pH range and physiological conditions; no significant protein adsorption; and great magnetic properties including relaxivity and in vitro MRI. Further comparison of Cat-MDBC with its corresponding catechol-based multidentate random copolymer suggests the importance of the architecture of multidentate polymeric ligands for USNP-based MRI diagnosis." @default.
- W2299520011 created "2016-06-24" @default.
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- W2299520011 date "2015-10-08" @default.
- W2299520011 modified "2023-10-06" @default.
- W2299520011 title "Mussel-Inspired Multidentate Block Copolymer to Stabilize Ultrasmall Superparamagnetic Fe<sub>3</sub>O<sub>4</sub> for Magnetic Resonance Imaging Contrast Enhancement and Excellent Colloidal Stability" @default.
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- W2299520011 doi "https://doi.org/10.1021/acs.chemmater.5b03028" @default.
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