Matches in SemOpenAlex for { <https://semopenalex.org/work/W2299605826> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2299605826 endingPage "E384" @default.
- W2299605826 startingPage "E380" @default.
- W2299605826 abstract "Description of the recessive, homozygote obese Zucker rat (fafa) includes disorders of growth and reproduction. The aim of this study was to compare responsiveness of adenohypophyseal cells, obtained from male fafa rats and from their lean siblings, to growth hormone-releasing factor (GRF) and to luteinizing hormone-releasing hormone (LHRH). Pituitary cells were cultured for 4 days and were then challenged with either GRF-29 (the NH2-terminal 29 amino acid GRF peptide that expresses full biological activity of its parent 44 amino acid molecule) or [D-Trp6]LHRH (LHRH-A, an LHRH agonist). Medium was assayed for growth hormone (GH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) by radioimmunoassay. Dose-response curves were compared using the computer program ALLFIT. The median effective GRF-29 concentration (EC50) computed for hypophyseal cells cultured from lean animals (0.30 +/- 0.01 fM; means +/- SE of 4 experiments) was less (P less than 0.01) than that calculated for cells obtained from fafa rats (15.8 +/- 6.7 fM). In contrast, cells derived from lean littermates required a larger (EC50) concentration of LHRH-A than did gonadotrophs cultured from obese rats [58.2 +/- 1.2 vs. 10.7 +/- 1.2 pM (P less than 0.01) and 59.4 +/- 10.4 vs. 15.7 +/- 7.6 pM (P less than 0.05)] to secrete LH and FSH, respectively. Our data describe an attenuated pituitary response to GRF-29 and an enhanced response to LHRH-A in the fafa." @default.
- W2299605826 created "2016-06-24" @default.
- W2299605826 creator A5019473847 @default.
- W2299605826 creator A5021831733 @default.
- W2299605826 creator A5026792698 @default.
- W2299605826 creator A5026965044 @default.
- W2299605826 creator A5052911501 @default.
- W2299605826 creator A5073668341 @default.
- W2299605826 creator A5074803352 @default.
- W2299605826 date "1985-10-01" @default.
- W2299605826 modified "2023-09-25" @default.
- W2299605826 title "Adenohypophyseal response to hypophysiotropic hormones in male obese Zucker rats" @default.
- W2299605826 cites W1972083618 @default.
- W2299605826 cites W2000140506 @default.
- W2299605826 cites W2001998235 @default.
- W2299605826 cites W2007657527 @default.
- W2299605826 cites W2014205713 @default.
- W2299605826 cites W2015019215 @default.
- W2299605826 cites W2025381000 @default.
- W2299605826 cites W2040024990 @default.
- W2299605826 cites W2063587143 @default.
- W2299605826 cites W2078681510 @default.
- W2299605826 cites W2087861136 @default.
- W2299605826 cites W2089584688 @default.
- W2299605826 cites W2091176662 @default.
- W2299605826 cites W2091837377 @default.
- W2299605826 cites W2126773160 @default.
- W2299605826 cites W2134433172 @default.
- W2299605826 cites W2152604497 @default.
- W2299605826 cites W2316831017 @default.
- W2299605826 cites W2332964537 @default.
- W2299605826 doi "https://doi.org/10.1152/ajpendo.1985.249.4.e380" @default.
- W2299605826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2864860" @default.
- W2299605826 hasPublicationYear "1985" @default.
- W2299605826 type Work @default.
- W2299605826 sameAs 2299605826 @default.
- W2299605826 citedByCount "6" @default.
- W2299605826 crossrefType "journal-article" @default.
- W2299605826 hasAuthorship W2299605826A5019473847 @default.
- W2299605826 hasAuthorship W2299605826A5021831733 @default.
- W2299605826 hasAuthorship W2299605826A5026792698 @default.
- W2299605826 hasAuthorship W2299605826A5026965044 @default.
- W2299605826 hasAuthorship W2299605826A5052911501 @default.
- W2299605826 hasAuthorship W2299605826A5073668341 @default.
- W2299605826 hasAuthorship W2299605826A5074803352 @default.
- W2299605826 hasConcept C126322002 @default.
- W2299605826 hasConcept C134018914 @default.
- W2299605826 hasConcept C170493617 @default.
- W2299605826 hasConcept C176685330 @default.
- W2299605826 hasConcept C185592680 @default.
- W2299605826 hasConcept C197012351 @default.
- W2299605826 hasConcept C2777658017 @default.
- W2299605826 hasConcept C2778575703 @default.
- W2299605826 hasConcept C2778938600 @default.
- W2299605826 hasConcept C2779279165 @default.
- W2299605826 hasConcept C56191518 @default.
- W2299605826 hasConcept C71315377 @default.
- W2299605826 hasConcept C71924100 @default.
- W2299605826 hasConcept C86803240 @default.
- W2299605826 hasConceptScore W2299605826C126322002 @default.
- W2299605826 hasConceptScore W2299605826C134018914 @default.
- W2299605826 hasConceptScore W2299605826C170493617 @default.
- W2299605826 hasConceptScore W2299605826C176685330 @default.
- W2299605826 hasConceptScore W2299605826C185592680 @default.
- W2299605826 hasConceptScore W2299605826C197012351 @default.
- W2299605826 hasConceptScore W2299605826C2777658017 @default.
- W2299605826 hasConceptScore W2299605826C2778575703 @default.
- W2299605826 hasConceptScore W2299605826C2778938600 @default.
- W2299605826 hasConceptScore W2299605826C2779279165 @default.
- W2299605826 hasConceptScore W2299605826C56191518 @default.
- W2299605826 hasConceptScore W2299605826C71315377 @default.
- W2299605826 hasConceptScore W2299605826C71924100 @default.
- W2299605826 hasConceptScore W2299605826C86803240 @default.
- W2299605826 hasIssue "4" @default.
- W2299605826 hasLocation W22996058261 @default.
- W2299605826 hasLocation W22996058262 @default.
- W2299605826 hasOpenAccess W2299605826 @default.
- W2299605826 hasPrimaryLocation W22996058261 @default.
- W2299605826 hasRelatedWork W1990896009 @default.
- W2299605826 hasRelatedWork W2013753219 @default.
- W2299605826 hasRelatedWork W2024553435 @default.
- W2299605826 hasRelatedWork W2027703819 @default.
- W2299605826 hasRelatedWork W2079195384 @default.
- W2299605826 hasRelatedWork W2093001829 @default.
- W2299605826 hasRelatedWork W2183517067 @default.
- W2299605826 hasRelatedWork W2299605826 @default.
- W2299605826 hasRelatedWork W4240693411 @default.
- W2299605826 hasRelatedWork W1994059275 @default.
- W2299605826 hasVolume "249" @default.
- W2299605826 isParatext "false" @default.
- W2299605826 isRetracted "false" @default.
- W2299605826 magId "2299605826" @default.
- W2299605826 workType "article" @default.