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- W2299693436 abstract "Mutations of the epigenetic enzymes isocitrate dehydrogenase (IDH) 1 and 2, and the methylcytosine dioxygenase ‘ten–eleven translocation 2’ (TET2), are common in human myeloid malignancies and drivers of these disorders but the underlying mechanisms remain obscure. This review examines mutant IDH1/2 and TET2 enzymes in the context of responses to DNA damage and their potential involvement in age-related genomic instability. The clinical relevance of these findings and their potential application in novel therapeutic strategies is also discussed." @default.
- W2299693436 created "2016-06-24" @default.
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- W2299693436 date "2016-03-15" @default.
- W2299693436 modified "2023-10-14" @default.
- W2299693436 title "Roles of IDH1/2 and TET2 mutations in myeloid disorders" @default.
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- W2299693436 doi "https://doi.org/10.1007/s12185-016-1973-7" @default.
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