FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2299694026> ?p ?o ?g. }

• W2299694026 abstract "Recent data have linked hypoxia, a classic feature of the tumor microenvironment, to the function of specific microRNAs (miRNAs); however, whether hypoxia affects other types of noncoding transcripts is currently unknown. Starting from a genomewide expression profiling, we demonstrate for the first time a functional link between oxygen deprivation and the modulation of long noncoding transcripts from ultraconserved regions, termed transcribed-ultraconserved regions (T-UCRs). Interestingly, several hypoxia-upregulated T-UCRs, henceforth named ‘hypoxia-induced noncoding ultraconserved transcripts’ (HINCUTs), are also overexpressed in clinical samples from colon cancer patients. We show that these T-UCRs are predominantly nuclear and that the hypoxia-inducible factor (HIF) is at least partly responsible for the induction of several members of this group. One specific HINCUT, uc.475 (or HINCUT-1) is part of a retained intron of the host protein-coding gene, O-linked N-acetylglucosamine transferase, which is overexpressed in epithelial cancer types. Consistent with the hypothesis that T-UCRs have important function in tumor formation, HINCUT-1 supports cell proliferation specifically under hypoxic conditions and may be critical for optimal O-GlcNAcylation of proteins when oxygen tension is limiting. Our data gives a first glimpse of a novel functional hypoxic network comprising protein-coding transcripts and noncoding RNAs (ncRNAs) from the T-UCRs category. Cell Death and Differentiation advance online publication, 13 September 2013; doi:10.1038/cdd.2013.119" @default.
• W2299694026 created "2016-06-24" @default.
• W2299694026 creator A5001854674 @default.
• W2299694026 creator A5002911824 @default.
• W2299694026 creator A5013346680 @default.
• W2299694026 creator A5013673358 @default.
• W2299694026 creator A5013938672 @default.
• W2299694026 creator A5017429478 @default.
• W2299694026 creator A5022351354 @default.
• W2299694026 creator A5022533710 @default.
• W2299694026 creator A5023933781 @default.
• W2299694026 creator A5023998618 @default.
• W2299694026 creator A5024349157 @default.
• W2299694026 creator A5024456614 @default.
• W2299694026 creator A5028018177 @default.
• W2299694026 creator A5029913023 @default.
• W2299694026 creator A5030426208 @default.
• W2299694026 creator A5039870917 @default.
• W2299694026 creator A5044003367 @default.
• W2299694026 creator A5053664752 @default.
• W2299694026 creator A5057769363 @default.
• W2299694026 creator A5069116689 @default.
• W2299694026 creator A5073051489 @default.
• W2299694026 creator A5077110623 @default.
• W2299694026 creator A5087506952 @default.
• W2299694026 date "2013-12-01" @default.
• W2299694026 modified "2023-09-23" @default.
• W2299694026 title "HINCUTs in cancer: hypoxia-induced noncoding ultraconserved transcripts" @default.
• W2299694026 cites W1493048246 @default.
• W2299694026 cites W1568866400 @default.
• W2299694026 cites W1783181079 @default.
• W2299694026 cites W1946993828 @default.
• W2299694026 cites W1964361484 @default.
• W2299694026 cites W1988935612 @default.
• W2299694026 cites W1996760543 @default.
• W2299694026 cites W1998016881 @default.
• W2299694026 cites W2009300653 @default.
• W2299694026 cites W2011900211 @default.
• W2299694026 cites W2012709143 @default.
• W2299694026 cites W2022428368 @default.
• W2299694026 cites W2025310815 @default.
• W2299694026 cites W2026249810 @default.
• W2299694026 cites W2030047242 @default.
• W2299694026 cites W2031087463 @default.
• W2299694026 cites W2035837644 @default.
• W2299694026 cites W2040031153 @default.
• W2299694026 cites W2040170958 @default.
• W2299694026 cites W2041825143 @default.
• W2299694026 cites W2041967294 @default.
• W2299694026 cites W2042720937 @default.
• W2299694026 cites W2057587811 @default.
• W2299694026 cites W2058876100 @default.
• W2299694026 cites W2067410483 @default.
• W2299694026 cites W2079492290 @default.
• W2299694026 cites W2087408461 @default.
• W2299694026 cites W2089467855 @default.
• W2299694026 cites W2098740402 @default.
• W2299694026 cites W2100990361 @default.
• W2299694026 cites W2103642791 @default.
• W2299694026 cites W2107277218 @default.
• W2299694026 cites W2109550992 @default.
• W2299694026 cites W2115379981 @default.
• W2299694026 cites W2115744888 @default.
• W2299694026 cites W2116000203 @default.
• W2299694026 cites W2117242459 @default.
• W2299694026 cites W2128016314 @default.
• W2299694026 cites W2134033103 @default.
• W2299694026 cites W2142912355 @default.
• W2299694026 cites W2152903729 @default.
• W2299694026 cites W2155301446 @default.
• W2299694026 cites W2159614750 @default.
• W2299694026 cites W2166179294 @default.
• W2299694026 cites W2166898290 @default.
• W2299694026 cites W2172268272 @default.
• W2299694026 hasPublicationYear "2013" @default.
• W2299694026 type Work @default.
• W2299694026 sameAs 2299694026 @default.
• W2299694026 citedByCount "0" @default.
• W2299694026 crossrefType "journal-article" @default.
• W2299694026 hasAuthorship W2299694026A5001854674 @default.
• W2299694026 hasAuthorship W2299694026A5002911824 @default.
• W2299694026 hasAuthorship W2299694026A5013346680 @default.
• W2299694026 hasAuthorship W2299694026A5013673358 @default.
• W2299694026 hasAuthorship W2299694026A5013938672 @default.
• W2299694026 hasAuthorship W2299694026A5017429478 @default.
• W2299694026 hasAuthorship W2299694026A5022351354 @default.
• W2299694026 hasAuthorship W2299694026A5022533710 @default.
• W2299694026 hasAuthorship W2299694026A5023933781 @default.
• W2299694026 hasAuthorship W2299694026A5023998618 @default.
• W2299694026 hasAuthorship W2299694026A5024349157 @default.
• W2299694026 hasAuthorship W2299694026A5024456614 @default.
• W2299694026 hasAuthorship W2299694026A5028018177 @default.
• W2299694026 hasAuthorship W2299694026A5029913023 @default.
• W2299694026 hasAuthorship W2299694026A5030426208 @default.
• W2299694026 hasAuthorship W2299694026A5039870917 @default.
• W2299694026 hasAuthorship W2299694026A5044003367 @default.
• W2299694026 hasAuthorship W2299694026A5053664752 @default.
• W2299694026 hasAuthorship W2299694026A5057769363 @default.
• W2299694026 hasAuthorship W2299694026A5069116689 @default.
• W2299694026 hasAuthorship W2299694026A5073051489 @default.

• next