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- W2299697746 abstract "Participation of α-synuclein (ASN) in the pathogenesis of Parkinson’s disease is undeniable. This protein is important for functioning of neurons. Conformational changes in ASN and its aggregation result in neurodegeneration. Therefore, the factors preventing aggregation need to be identified. The search for the potential agents preventing fibrillation of proteins in neurodegenerative diseases has also involved polymers such as dendrimers. The aim of this study was to examine the role of carbosilane dendrimers (CBS) in α-synuclein fibrillation process and to assess the structural changes in α-synuclein under the influence of dendrimers. ASN interactions with carbosilane dendrimers were examined by measuring the zeta potential. The fibrillation and structural changes were examined using CD spectroscopy. The results obtained in this study suggest that carbosilane dendrimers can be potential inhibitors of ASN fibril formation. The fact that dendrimers can prevent ASN fibrillation in suspension is important for further research because it may lead to the design of effective pharmacological strategies." @default.
- W2299697746 created "2016-06-24" @default.
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- W2299697746 date "2015-01-01" @default.
- W2299697746 modified "2023-09-23" @default.
- W2299697746 title "Carbosilane dendrimers affect the fibrillation of α-synuclein" @default.
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- W2299697746 doi "https://doi.org/10.1063/1.4937302" @default.
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