FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2299804566> ?p ?o ?g. }

• W2299804566 endingPage "3156" @default.
• W2299804566 startingPage "3151" @default.
• W2299804566 abstract "Abstract p53 overexpression has been found to be a fairly common feature in high grade lymphomas in the majority of tumoral cells. The results vary from series to series, from 25% to 33% of cases. To assess whether immunohistochemical positivity for p53 correlated with the presence of structural gene abnormalities, DNA from 16 non-Hodgkin's lymphomas with high and low p53 values was amplified and sequenced to determine the existence of point mutations in the highly conserved regions of the p53 gene. In the group of 8 cases containing high levels of protein, 3 cases showed missense point mutations at the codons mapping between exons 5 through 8. Of the 8 cases of tumors containing undetectable or low levels of p53 protein, 1 case presented a nonsense point mutation giving a stop codon. No missense mutations were detected in this group. The finding of p53 mutations in 4 of 16 cases confirms the presence of p53 gene mutations in high grade lymphomas distributed over different histologic groups. These include Burkitt's lymphoma, together with centroblastic, immunoblastic, and large cell lymphoma of mucosa origin. Nevertheless, the absence of mutations in 5 of the 8 cases that overexpressed p53 suggests that the nuclear or cytoplasmic stabilization of p53 protein could also depend on other factors. The absence of detectable levels of p53 protein cannot discount the existence of p53 mutations, as is shown by a case of Burkitt's lymphoma in which a nonsense mutation was detected. The impact of this range of p53 alterations on clinical course and treatment response of the patients deserves to be explored, in an attempt to differentiate the specific consequences of each one." @default.
• W2299804566 created "2016-06-24" @default.
• W2299804566 creator A5027382318 @default.
• W2299804566 creator A5032887007 @default.
• W2299804566 creator A5036938314 @default.
• W2299804566 creator A5044137179 @default.
• W2299804566 creator A5050273913 @default.
• W2299804566 creator A5060687832 @default.
• W2299804566 creator A5069484088 @default.
• W2299804566 creator A5080867901 @default.
• W2299804566 creator A5086419086 @default.
• W2299804566 creator A5090221356 @default.
• W2299804566 date "1993-11-15" @default.
• W2299804566 modified "2023-10-18" @default.
• W2299804566 title "The expression of p53 protein in non-Hodgkin's lymphomas is not always dependent on p53 gene mutations" @default.
• W2299804566 cites W1224143281 @default.
• W2299804566 cites W1480986388 @default.
• W2299804566 cites W1502887285 @default.
• W2299804566 cites W1542367364 @default.
• W2299804566 cites W1579724792 @default.
• W2299804566 cites W1580617714 @default.
• W2299804566 cites W1805678211 @default.
• W2299804566 cites W1908549540 @default.
• W2299804566 cites W1926834804 @default.
• W2299804566 cites W1935791347 @default.
• W2299804566 cites W196344020 @default.
• W2299804566 cites W1986684060 @default.
• W2299804566 cites W1997646834 @default.
• W2299804566 cites W2001258296 @default.
• W2299804566 cites W2033106673 @default.
• W2299804566 cites W2039382131 @default.
• W2299804566 cites W2040876807 @default.
• W2299804566 cites W2042316019 @default.
• W2299804566 cites W2043849891 @default.
• W2299804566 cites W2051226734 @default.
• W2299804566 cites W2054549064 @default.
• W2299804566 cites W2057397700 @default.
• W2299804566 cites W2067443503 @default.
• W2299804566 cites W2068909560 @default.
• W2299804566 cites W2072281036 @default.
• W2299804566 cites W2072564410 @default.
• W2299804566 cites W2074114480 @default.
• W2299804566 cites W2082668438 @default.
• W2299804566 cites W2085172497 @default.
• W2299804566 cites W2091151265 @default.
• W2299804566 cites W2092433246 @default.
• W2299804566 cites W2111703821 @default.
• W2299804566 cites W2124314287 @default.
• W2299804566 cites W2129797996 @default.
• W2299804566 cites W2139498321 @default.
• W2299804566 cites W2146642286 @default.
• W2299804566 cites W2294430528 @default.
• W2299804566 cites W2343119391 @default.
• W2299804566 cites W2395405153 @default.
• W2299804566 cites W2397323158 @default.
• W2299804566 cites W2401743239 @default.
• W2299804566 cites W2411307169 @default.
• W2299804566 cites W2411855208 @default.
• W2299804566 cites W2414420602 @default.
• W2299804566 cites W2415961488 @default.
• W2299804566 cites W2473890412 @default.
• W2299804566 cites W2505185289 @default.
• W2299804566 cites W285954854 @default.
• W2299804566 cites W3110939446 @default.
• W2299804566 cites W569951484 @default.
• W2299804566 cites W80989898 @default.
• W2299804566 doi "https://doi.org/10.1182/blood.v82.10.3151.3151" @default.
• W2299804566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8219204" @default.
• W2299804566 hasPublicationYear "1993" @default.
• W2299804566 type Work @default.
• W2299804566 sameAs 2299804566 @default.
• W2299804566 citedByCount "102" @default.
• W2299804566 countsByYear W22998045662012 @default.
• W2299804566 countsByYear W22998045662014 @default.
• W2299804566 countsByYear W22998045662017 @default.
• W2299804566 countsByYear W22998045662022 @default.
• W2299804566 crossrefType "journal-article" @default.
• W2299804566 hasAuthorship W2299804566A5027382318 @default.
• W2299804566 hasAuthorship W2299804566A5032887007 @default.
• W2299804566 hasAuthorship W2299804566A5036938314 @default.
• W2299804566 hasAuthorship W2299804566A5044137179 @default.
• W2299804566 hasAuthorship W2299804566A5050273913 @default.
• W2299804566 hasAuthorship W2299804566A5060687832 @default.
• W2299804566 hasAuthorship W2299804566A5069484088 @default.
• W2299804566 hasAuthorship W2299804566A5080867901 @default.
• W2299804566 hasAuthorship W2299804566A5086419086 @default.
• W2299804566 hasAuthorship W2299804566A5090221356 @default.
• W2299804566 hasBestOaLocation W22998045661 @default.
• W2299804566 hasConcept C104317684 @default.
• W2299804566 hasConcept C153911025 @default.
• W2299804566 hasConcept C176944494 @default.
• W2299804566 hasConcept C203014093 @default.
• W2299804566 hasConcept C2778264664 @default.
• W2299804566 hasConcept C2779338263 @default.
• W2299804566 hasConcept C2994225774 @default.
• W2299804566 hasConcept C36823959 @default.
• W2299804566 hasConcept C501734568 @default.
• W2299804566 hasConcept C502942594 @default.

• next