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- W2299836223 abstract "Kinetochores are macromolecular machines that drive eukaryotic chromosome segregation by interacting with centromeric DNA and spindle microtubules. While most eukaryotes possess conventional kinetochore proteins, evolutionarily distant kinetoplastid species have unconventional kinetochore proteins, composed of at least 19 proteins (KKT1–19). Polo-like kinase (PLK) is not a structural kinetochore component in either system. Here, we report the identification of an additional kinetochore protein, KKT20, in Trypanosoma brucei . KKT20 has sequence similarity with KKT2 and KKT3 in the Cys-rich region, and all three proteins have weak but significant similarity to the polo box domain (PBD) of PLK. These divergent PBDs of KKT2 and KKT20 are sufficient for kinetochore localization in vivo . We propose that the ancestral PLK acquired a Cys-rich region and then underwent gene duplication events to give rise to three structural kinetochore proteins in kinetoplastids." @default.
- W2299836223 created "2016-06-24" @default.
- W2299836223 creator A5031038205 @default.
- W2299836223 creator A5074968369 @default.
- W2299836223 date "2016-03-01" @default.
- W2299836223 modified "2023-09-25" @default.
- W2299836223 title "Divergent polo box domains underpin the unique kinetoplastid kinetochore" @default.
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- W2299836223 doi "https://doi.org/10.1098/rsob.150206" @default.
- W2299836223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4821238" @default.
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