Matches in SemOpenAlex for { <https://semopenalex.org/work/W2300143417> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2300143417 abstract "Systemic inflammation markedly increases the neurodepressive properties of general anesthetics, for reasons that have remained poorly understood. The pro-inflammatory cytokine interleukin-1 beta (IL-1β) increases the surface expression of γ-aminobutyric acid type A receptors (GABAARs), implying an increase in the number of receptors for anesthetics. In this thesis, it was first postulated that IL-1β increases the potentiation of GABAAR activity by anesthetics in vitro. The results showed that IL-1β-treatment of hippocampus neurons produced greater etomidate- and isoflurane-induced potentiation of GABAAR activity compared with vehicle-treated neurons. Subsequently, it was postulated that behavioural endpoints that are modified by GABAergic anesthetics would be enhanced by systemic inflammation. The results showed that systemic inflammation produced by lipopolysaccharide enhanced etomidate-mediated immobility, hypnosis, and amnesia, and isoflurane-mediated hypnosis in mice. In contrast, systemic inflammation did not alter isoflurane-mediated immobility. Together, this thesis supports the notion that systemic inflammation enhances the efficacy of general anesthetics that target GABAARs.%%%%MAST" @default.
- W2300143417 created "2016-06-24" @default.
- W2300143417 creator A5011503303 @default.
- W2300143417 date "2013-06-01" @default.
- W2300143417 modified "2023-09-23" @default.
- W2300143417 title "Systemic Inflammation Increases the Efficacy of Anesthetics that Target GABAA Receptors" @default.
- W2300143417 hasPublicationYear "2013" @default.
- W2300143417 type Work @default.
- W2300143417 sameAs 2300143417 @default.
- W2300143417 citedByCount "0" @default.
- W2300143417 crossrefType "dissertation" @default.
- W2300143417 hasAuthorship W2300143417A5011503303 @default.
- W2300143417 hasConcept C126322002 @default.
- W2300143417 hasConcept C168258287 @default.
- W2300143417 hasConcept C170493617 @default.
- W2300143417 hasConcept C203014093 @default.
- W2300143417 hasConcept C25274449 @default.
- W2300143417 hasConcept C2776252253 @default.
- W2300143417 hasConcept C2776277131 @default.
- W2300143417 hasConcept C2776359302 @default.
- W2300143417 hasConcept C2776914184 @default.
- W2300143417 hasConcept C2779676917 @default.
- W2300143417 hasConcept C42219234 @default.
- W2300143417 hasConcept C71924100 @default.
- W2300143417 hasConcept C98274493 @default.
- W2300143417 hasConceptScore W2300143417C126322002 @default.
- W2300143417 hasConceptScore W2300143417C168258287 @default.
- W2300143417 hasConceptScore W2300143417C170493617 @default.
- W2300143417 hasConceptScore W2300143417C203014093 @default.
- W2300143417 hasConceptScore W2300143417C25274449 @default.
- W2300143417 hasConceptScore W2300143417C2776252253 @default.
- W2300143417 hasConceptScore W2300143417C2776277131 @default.
- W2300143417 hasConceptScore W2300143417C2776359302 @default.
- W2300143417 hasConceptScore W2300143417C2776914184 @default.
- W2300143417 hasConceptScore W2300143417C2779676917 @default.
- W2300143417 hasConceptScore W2300143417C42219234 @default.
- W2300143417 hasConceptScore W2300143417C71924100 @default.
- W2300143417 hasConceptScore W2300143417C98274493 @default.
- W2300143417 hasLocation W23001434171 @default.
- W2300143417 hasOpenAccess W2300143417 @default.
- W2300143417 hasPrimaryLocation W23001434171 @default.
- W2300143417 hasRelatedWork W1997150539 @default.
- W2300143417 hasRelatedWork W2025287814 @default.
- W2300143417 hasRelatedWork W2030107887 @default.
- W2300143417 hasRelatedWork W2044584261 @default.
- W2300143417 hasRelatedWork W2046601077 @default.
- W2300143417 hasRelatedWork W2051384070 @default.
- W2300143417 hasRelatedWork W2057679076 @default.
- W2300143417 hasRelatedWork W2076336044 @default.
- W2300143417 hasRelatedWork W2088142555 @default.
- W2300143417 hasRelatedWork W2109415022 @default.
- W2300143417 hasRelatedWork W2371064896 @default.
- W2300143417 hasRelatedWork W2485963787 @default.
- W2300143417 hasRelatedWork W2604478455 @default.
- W2300143417 hasRelatedWork W2767981887 @default.
- W2300143417 hasRelatedWork W2772218995 @default.
- W2300143417 hasRelatedWork W2800286708 @default.
- W2300143417 hasRelatedWork W2998707963 @default.
- W2300143417 hasRelatedWork W2998943595 @default.
- W2300143417 hasRelatedWork W3026106756 @default.
- W2300143417 hasRelatedWork W3133420082 @default.
- W2300143417 isParatext "false" @default.
- W2300143417 isRetracted "false" @default.
- W2300143417 magId "2300143417" @default.
- W2300143417 workType "dissertation" @default.