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- W2300219290 abstract "Assessment of the tissue oxygenation is an important factor allowing to analyze various processes depending on the presence of oxygen. However, the oxygen sensitive probes can interact with proteins or lipids (depending on the hydrophobic character of the probe) what can interfere with the precise determination of the oxygen concentration. Dichlorotris(1,10-phenanthroline)-ruthenium(II)hydrate ([Ru(Phen)3]2+) is a water soluble non-phototoxic compound serving as a sensor of molecular oxygen. This type of heterocyclic ligands can also be used for antitumor, antibacterial and antiviral purposes. Thus, its interaction with carrier protein such as serum albumin is of high importance since this complex formation has a substantial influence on the in vivo distribution of the sensor.In this work, we have investigated the mechanism of [Ru(Phen)3]2+ interaction with human serum albumin (HSA), the most abundant protein in human plasma, by using different optical spectroscopy techniques: UV-visible absorption, fluorescence and Raman spectroscopies. The obtained experimental data suggest only weak interaction of [Ru(Phen)3]2+ with HSA (Kd= 64 μM). Further, Raman spectroscopy and surface-enhanced Raman spectroscopy allowed us to register so-called fingerprint vibrational spectra of both molecules as well as to detect small changes in the polypeptide backbone conformations induced by the [Ru(Phen)3]2+-molecule binding.AcknowledgementsThis work was funded by the contract APVV-0242-11, by the EU 7FP grant CELIM 316310 and by the project of the EU Structural Funds (ITMS 26240120040)." @default.
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- W2300219290 date "2016-02-01" @default.
- W2300219290 modified "2023-09-26" @default.
- W2300219290 title "Human Serum Albumin-[Ru(Phen)3]2+ Complex Formation Studied by Optical Spectroscopies" @default.
- W2300219290 doi "https://doi.org/10.1016/j.bpj.2015.11.325" @default.
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