FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2300254118> ?p ?o ?g. }

• W2300254118 endingPage "864" @default.
• W2300254118 startingPage "854" @default.
• W2300254118 abstract "Therapeutic perspectives have brought attention to the development of instruments to accurately evaluate the degree of pathology in patients with facioscapulohumeral muscular dystrophy. We aimed to analyze the type and extent of muscle involvement on magnetic resonance imaging (MRI) in a large cohort of patients representative of the broad clinical spectrum of this disease.Pelvic and lower limb muscle MRI scans of 269 symptomatic individuals and 19 nonpenetrant gene carriers were assessed. Comparative analysis of the upper girdle scan in 181 of these subjects was also performed.We found a peculiar susceptibility and resistance of particular muscles. Combined involvement of abdominal and hamstring muscles with iliopsoas sparing is common in facioscapulohumeral muscular dystrophy (67% of the patients). Adductor longus and/or rectus femoris, whose involvement can go clinically undetected, are often typically affected in early disease (69% of patients younger than 45 years). The extent of lesions on lower limb MRI showed a high correlation with overall clinical severity. One-fourth of the nonpenetrant gene carriers showed abnormalities on MRI. Hyperintensities on short-tau inversion recovery sequences, markers of active disease, were found in muscles without signs of fatty replacement in 35% of patients, representing early lesions.Our large-scale cross-sectional data provide preliminary evidence for the usefulness of MRI in clinical trials, and set the baseline for longitudinal studies. Muscle MRI can also be used for distinguishing facioscapulohumeral muscular dystrophy from other myopathies in selected cases. Finally, our results are consistent with a model that configures facioscapulohumeral muscular dystrophy as a muscle-by-muscle disease. Ann Neurol 2016;79:854-864." @default.
• W2300254118 created "2016-06-24" @default.
• W2300254118 creator A5000776432 @default.
• W2300254118 creator A5015272797 @default.
• W2300254118 creator A5066411369 @default.
• W2300254118 creator A5069606900 @default.
• W2300254118 creator A5077332238 @default.
• W2300254118 creator A5081295588 @default.
• W2300254118 creator A5088511358 @default.
• W2300254118 date "2016-04-04" @default.
• W2300254118 modified "2023-09-23" @default.
• W2300254118 title "Magnetic resonance imaging in a large cohort of facioscapulohumeral muscular dystrophy patients: Pattern refinement and implications for clinical trials" @default.
• W2300254118 cites W1181191418 @default.
• W2300254118 cites W1558257278 @default.
• W2300254118 cites W1759685647 @default.
• W2300254118 cites W1901326848 @default.
• W2300254118 cites W1904689509 @default.
• W2300254118 cites W1966082194 @default.
• W2300254118 cites W1972975683 @default.
• W2300254118 cites W1979547632 @default.
• W2300254118 cites W1996710773 @default.
• W2300254118 cites W2006356957 @default.
• W2300254118 cites W2006649304 @default.
• W2300254118 cites W2010087188 @default.
• W2300254118 cites W2024891925 @default.
• W2300254118 cites W2026556066 @default.
• W2300254118 cites W2029506711 @default.
• W2300254118 cites W2031438610 @default.
• W2300254118 cites W2037618365 @default.
• W2300254118 cites W2037761873 @default.
• W2300254118 cites W2041793850 @default.
• W2300254118 cites W2045260008 @default.
• W2300254118 cites W2050957628 @default.
• W2300254118 cites W2061046717 @default.
• W2300254118 cites W2086775164 @default.
• W2300254118 cites W2087817221 @default.
• W2300254118 cites W2094227004 @default.
• W2300254118 cites W2109889650 @default.
• W2300254118 cites W2110363356 @default.
• W2300254118 cites W2114295328 @default.
• W2300254118 cites W2116578012 @default.
• W2300254118 cites W2137339327 @default.
• W2300254118 cites W2143758903 @default.
• W2300254118 cites W2143782097 @default.
• W2300254118 cites W2148917862 @default.
• W2300254118 cites W2162121601 @default.
• W2300254118 cites W2165192327 @default.
• W2300254118 cites W2167689669 @default.
• W2300254118 cites W2170021941 @default.
• W2300254118 cites W2171938221 @default.
• W2300254118 cites W2248797975 @default.
• W2300254118 cites W2731791598 @default.
• W2300254118 doi "https://doi.org/10.1002/ana.24640" @default.
• W2300254118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26994363" @default.
• W2300254118 hasPublicationYear "2016" @default.
• W2300254118 type Work @default.
• W2300254118 sameAs 2300254118 @default.
• W2300254118 citedByCount "79" @default.
• W2300254118 countsByYear W23002541182016 @default.
• W2300254118 countsByYear W23002541182017 @default.
• W2300254118 countsByYear W23002541182018 @default.
• W2300254118 countsByYear W23002541182019 @default.
• W2300254118 countsByYear W23002541182020 @default.
• W2300254118 countsByYear W23002541182021 @default.
• W2300254118 countsByYear W23002541182022 @default.
• W2300254118 countsByYear W23002541182023 @default.
• W2300254118 crossrefType "journal-article" @default.
• W2300254118 hasAuthorship W2300254118A5000776432 @default.
• W2300254118 hasAuthorship W2300254118A5015272797 @default.
• W2300254118 hasAuthorship W2300254118A5066411369 @default.
• W2300254118 hasAuthorship W2300254118A5069606900 @default.
• W2300254118 hasAuthorship W2300254118A5077332238 @default.
• W2300254118 hasAuthorship W2300254118A5081295588 @default.
• W2300254118 hasAuthorship W2300254118A5088511358 @default.
• W2300254118 hasConcept C126322002 @default.
• W2300254118 hasConcept C126838900 @default.
• W2300254118 hasConcept C143409427 @default.
• W2300254118 hasConcept C2776141760 @default.
• W2300254118 hasConcept C2779030066 @default.
• W2300254118 hasConcept C2779981540 @default.
• W2300254118 hasConcept C535046627 @default.
• W2300254118 hasConcept C71924100 @default.
• W2300254118 hasConcept C72563966 @default.
• W2300254118 hasConcept C99508421 @default.
• W2300254118 hasConceptScore W2300254118C126322002 @default.
• W2300254118 hasConceptScore W2300254118C126838900 @default.
• W2300254118 hasConceptScore W2300254118C143409427 @default.
• W2300254118 hasConceptScore W2300254118C2776141760 @default.
• W2300254118 hasConceptScore W2300254118C2779030066 @default.
• W2300254118 hasConceptScore W2300254118C2779981540 @default.
• W2300254118 hasConceptScore W2300254118C535046627 @default.
• W2300254118 hasConceptScore W2300254118C71924100 @default.
• W2300254118 hasConceptScore W2300254118C72563966 @default.
• W2300254118 hasConceptScore W2300254118C99508421 @default.
• W2300254118 hasIssue "5" @default.
• W2300254118 hasLocation W23002541181 @default.
• W2300254118 hasLocation W23002541182 @default.
• W2300254118 hasOpenAccess W2300254118 @default.

• next