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• W23002795 startingPage "78" @default.
• W23002795 abstract "Proteolytic activities arise during the activation of several biological plasma systems. More than one proteinase is necessary for the whole reaction sequence of certain of these systems. Thus the clotting system (Fig. 1) shows four different proteolytic activities (factors XII, XI, X, and II) and at least 3 antiproteinases are involved in the inhibition of these enzymes. In the classical sequence of the complement system (Fig. 2) 4 different proteolytic activities have already been demonstrated: Clr, Cls, C3-convertase, and C3-dependent peptidase. Normal C3-convertase activity arises by the molecular association of C2a and C4b(C4, 2), whereas C3 dependent peptidase (C4, 2, 3) needs, in addition, the association of C3b. Only the first 2 enzymes are actually known to be specifically inhibited by a plasma inhibitor (Cl inactivator or C1 INA), whereas no plasma antiproteinase has been identified for the other enzymes. Indeed the protein known as C3b inactivator is itself a proteolytic enzyme cleaving C3b into two additional fragments (in the same way as does trypsin) C3c and C3d. Again no inhibiting antiproteinase is actually known. In the alternate pathway of complement activation two other proteolytic activities are found corresponding to C3 Proactivator (C3PA) convertase and the C3 activator (Fig. 2) but none of the known plasmatic antiproteinases seem to be involved although the absence of a plasmatic inhibitor of C 3 PA convertase has been described in certain pathological conditions." @default.
• W23002795 created "2016-06-24" @default.
• W23002795 creator A5001410923 @default.
• W23002795 creator A5032897651 @default.
• W23002795 date "1974-01-01" @default.
• W23002795 modified "2023-09-25" @default.
• W23002795 title "Biology and Pathology of Plasma Proteinase Inhibitors" @default.
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