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• W2300309871 abstract "// Wenmiao Wang 1, 2 , Peng Yuan 1 , Dianke Yu 3 , Feng Du 1 , Anjie Zhu 1 , Qing Li 1 , Pin Zhang 1 , Dongxin Lin 3 , Binghe Xu 1 1 Department of Medical Oncology, Cancer Institute and Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, P.R. China 2 Phase I Clinical Trial Center, Beijing Shijitan Hospital, Capital Medical University, The 9th Clinical College, Beijing, P.R. China 3 Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, P.R. China Correspondence to: Peng Yuan, e-mail: yuanpeng01@hotmail.com Binghe Xu, e-mail: bhxu@hotmail.com Keywords: triple-negative breast cancer, FABP4, genetic variant, 3′-untranslated regions, prognosis Received: July 13, 2015      Accepted: January 29, 2016      Published: March 4, 2016 ABSTRACT Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis and high heterogeneity. The aim of this study was to screen patients for single-nucleotide polymorphisms (SNPs) associated with the prognosis of TNBC. Database-derived SNPs (NextBio, Ensembl, NCBI and MirSNP) located in the 3′-untranslated regions (3′-UTRs) of genes that are differentially expressed in breast cancer were selected. The possible associations between 111 SNPs and progression risk among 323 TNBC patients were investigated using a two-step case-control study with a discovery cohort (n=162) and a validation cohort (n=161). We identified the rs1054135 SNP in the adipocyte fatty acid binding protein 4 ( FABP4 ) gene as a predictor of TNBC recurrence. The G allele of rs1054135 was associated with a reduced risk of disease progression as well as a prolonged disease-free survival time (DFS), with a hazard ratio (HR) for recurrence in the combined sample of 0.269 [95%CI: 0.098−0.735; P =0.001]. Notably, for individuals having the rs1054135 SNP with the AA/AG genotype, the magnitude of increased tumour recurrence risk for overweight patients (BMI≥25kg/m 2 ) was significantly elevated (HR2.53; 95%CI: 1.06–6.03). Immunohistochemical staining of adipocytes adjacent to TNBC tissues showed that the expression level of FABP4 was statistically significantly lower in patients with the rs1054135 - GG genotype and those in the disease-free group ( P =0.0004 and P =0.0091, respectively). These results suggested that the expression of a lipid metabolism-related gene and an important SNP in the 3′-UTR of FABP4 are associated with TNBC prognosis, which may aid in the screening of high-risk patients with TNBC recurrence and the development of novel chemotherapeutic agents." @default.
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• W2300309871 date "2016-03-04" @default.
• W2300309871 modified "2023-09-23" @default.
• W2300309871 title "A single-nucleotide polymorphism in the 3′-UTR region of the adipocyte fatty acid binding protein 4 gene is associated with prognosis of triple-negative breast cancer" @default.
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• W2300309871 doi "https://doi.org/10.18632/oncotarget.7920" @default.
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