Matches in SemOpenAlex for { <https://semopenalex.org/work/W2300311146> ?p ?o ?g. }
- W2300311146 endingPage "825" @default.
- W2300311146 startingPage "815" @default.
- W2300311146 abstract "The risk of developing post-traumatic osteoarthritis (PTOA) following joint injury is high. Furthering our understanding of the molecular mechanisms underlying PTOA and/or identifying novel biomarkers for early detection may help to improve treatment outcomes. Increased expression of integrin α1β1 and inhibition of epidermal growth factor receptor (EGFR) signaling protect the knee from spontaneous OA; however, the impact of the integrin α1β1/EGFR axis on PTOA is currently unknown. We sought to determine metabolic changes in serum samples collected from wild-type and integrin α1-null mice that underwent surgery to destabilize the medial meniscus and were treated with the EGFR inhibitor erlotinib. Following 1H nuclear magnetic resonance spectroscopy, we generated multivariate statistical models that distinguished between the metabolic profiles of erlotinib- versus vehicle-treated mice and the integrin α1-null versus wild-type mouse genotype. Our results show the sex-dependent effects of erlotinib treatment and highlight glutamine as a metabolite that counteracts this treatment. Furthermore, we identified a set of metabolites associated with increased reactive oxygen species production, susceptibility to OA, and regulation of TRP channels in α1-null mice. Our study indicates that systemic pharmacological and genetic factors have a greater effect on serum metabolic profiles than site-specific factors such as surgery." @default.
- W2300311146 created "2016-06-24" @default.
- W2300311146 creator A5013700047 @default.
- W2300311146 creator A5042190192 @default.
- W2300311146 creator A5054696804 @default.
- W2300311146 creator A5075914955 @default.
- W2300311146 creator A5078723552 @default.
- W2300311146 date "2016-01-28" @default.
- W2300311146 modified "2023-09-27" @default.
- W2300311146 title "Serum Metabolite Profiles Are Altered by Erlotinib Treatment and the Integrin α1-Null Genotype but Not by Post-Traumatic Osteoarthritis" @default.
- W2300311146 cites W1487036716 @default.
- W2300311146 cites W1535455654 @default.
- W2300311146 cites W1560638706 @default.
- W2300311146 cites W1573431383 @default.
- W2300311146 cites W160037892 @default.
- W2300311146 cites W1779286308 @default.
- W2300311146 cites W1924772894 @default.
- W2300311146 cites W1945361972 @default.
- W2300311146 cites W1967136516 @default.
- W2300311146 cites W1968813633 @default.
- W2300311146 cites W1978450685 @default.
- W2300311146 cites W1978864283 @default.
- W2300311146 cites W1980397480 @default.
- W2300311146 cites W198304791 @default.
- W2300311146 cites W1985398792 @default.
- W2300311146 cites W1987627808 @default.
- W2300311146 cites W1989069744 @default.
- W2300311146 cites W1995051707 @default.
- W2300311146 cites W1995195447 @default.
- W2300311146 cites W2002251686 @default.
- W2300311146 cites W2003414488 @default.
- W2300311146 cites W2006638034 @default.
- W2300311146 cites W2006985579 @default.
- W2300311146 cites W2009033874 @default.
- W2300311146 cites W2013607204 @default.
- W2300311146 cites W2021663660 @default.
- W2300311146 cites W2024759250 @default.
- W2300311146 cites W2028331558 @default.
- W2300311146 cites W2039129408 @default.
- W2300311146 cites W2041452359 @default.
- W2300311146 cites W2044158587 @default.
- W2300311146 cites W2044633090 @default.
- W2300311146 cites W2045074061 @default.
- W2300311146 cites W2046347363 @default.
- W2300311146 cites W2047270673 @default.
- W2300311146 cites W2051295562 @default.
- W2300311146 cites W2051341131 @default.
- W2300311146 cites W2051920190 @default.
- W2300311146 cites W2057570479 @default.
- W2300311146 cites W2058544514 @default.
- W2300311146 cites W2059842158 @default.
- W2300311146 cites W2060952451 @default.
- W2300311146 cites W2064896821 @default.
- W2300311146 cites W2072063893 @default.
- W2300311146 cites W2076124709 @default.
- W2300311146 cites W2077562320 @default.
- W2300311146 cites W2078560698 @default.
- W2300311146 cites W2080669049 @default.
- W2300311146 cites W2081383662 @default.
- W2300311146 cites W2083391305 @default.
- W2300311146 cites W2086434606 @default.
- W2300311146 cites W2100696210 @default.
- W2300311146 cites W2113462050 @default.
- W2300311146 cites W2119752060 @default.
- W2300311146 cites W2122556757 @default.
- W2300311146 cites W2124911115 @default.
- W2300311146 cites W2130513475 @default.
- W2300311146 cites W2131848047 @default.
- W2300311146 cites W2132650643 @default.
- W2300311146 cites W2135095677 @default.
- W2300311146 cites W2138695033 @default.
- W2300311146 cites W2140207977 @default.
- W2300311146 cites W2143708659 @default.
- W2300311146 cites W2148485555 @default.
- W2300311146 cites W2153037067 @default.
- W2300311146 cites W2154631167 @default.
- W2300311146 cites W2159675211 @default.
- W2300311146 cites W2162515752 @default.
- W2300311146 cites W2305234952 @default.
- W2300311146 cites W2399662018 @default.
- W2300311146 cites W4252108671 @default.
- W2300311146 cites W1821016226 @default.
- W2300311146 doi "https://doi.org/10.1021/acs.jproteome.5b00719" @default.
- W2300311146 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4779398" @default.
- W2300311146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26784366" @default.
- W2300311146 hasPublicationYear "2016" @default.
- W2300311146 type Work @default.
- W2300311146 sameAs 2300311146 @default.
- W2300311146 citedByCount "7" @default.
- W2300311146 countsByYear W23003111462018 @default.
- W2300311146 countsByYear W23003111462020 @default.
- W2300311146 countsByYear W23003111462022 @default.
- W2300311146 crossrefType "journal-article" @default.
- W2300311146 hasAuthorship W2300311146A5013700047 @default.
- W2300311146 hasAuthorship W2300311146A5042190192 @default.
- W2300311146 hasAuthorship W2300311146A5054696804 @default.
- W2300311146 hasAuthorship W2300311146A5075914955 @default.
- W2300311146 hasAuthorship W2300311146A5078723552 @default.