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• W2300320186 abstract "A series of novel symmetrical trans-bis-Schiff bases (11a, 11b, 11c, 11d, 11e, 11f, 11g, 11h, 11i, 11j, 11k, 11l, 11m) were designed and prepared as novel anticancer analogues, with the trans-configuration confirmed by X-ray diffraction. Preliminary inhibitory effects of these compounds on CML K562 cell growth were investigated, and the potential analogue 11e showed an excellent anti-leukemia activity (IC50=6.35 μg/mL), which is higher than that of the clinical drug 5-fluorouracil (IC50=8.48 μg/mL). Complete assignments had been achieved for the title compounds by spectroscopic techniques, and their structure–activity relationships have been studied." @default.
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• W2300320186 date "2013-09-13" @default.
• W2300320186 modified "2023-09-25" @default.
• W2300320186 title "Novel Symmetrical<i>trans</i>-Bis-Schiff Bases of<i>N</i>-Substituted-4- piperidones: Synthesis, Characterization, and Preliminary Antileukemia Activity Mensurations" @default.
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• W2300320186 doi "https://doi.org/10.1002/jhet.916" @default.
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