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- W2300320512 abstract "The synthesis of two groups of aminochloropyrimidine bis-intercalators with different lipophilicity or limited flexibility of linkers as potential DNA intercalators is described. The lipophilic linkers in the synthesized bis-intercalators are represented by alternating methylene groups and oxygen atoms in a chain, with a pyrimidine ring containing an amino group and a chloro group at each end (10, 11, 12, 13). The bis-intercalators with limited flexibility contain chains with two benzene rings (15, 16, 17, 18, 19). All these compounds were obtained by nucleophilic substitution of 2-amino-4,6-dichloropyrimidine (1). The spectral data and other physical properties of the new compounds are presented. The anticancer activity of these newly synthesized compounds is also reported. Compounds 7 and 8 described in one of our previous publications display good anticancer activity against murine lymphoma." @default.
- W2300320512 created "2016-06-24" @default.
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- W2300320512 date "2014-03-17" @default.
- W2300320512 modified "2023-09-26" @default.
- W2300320512 title "Synthesis andIn VitroEvaluation of Bis-intercalators with Varied Linkers between Aminochloropyrimidine Rings" @default.
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- W2300320512 doi "https://doi.org/10.1002/jhet.1767" @default.
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