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- W2300366124 abstract "Eosinophils play proinflammatory roles in helminth infections and allergic diseases. Under steady-state conditions, eosinophils are abundantly found in the small intestinal lamina propria, but their physiological function is largely unexplored. In this study, we found that small intestinal eosinophils down-regulate Th17 cells. Th17 cells in the small intestine were markedly increased in the ΔdblGATA-1 mice lacking eosinophils, and an inverse correlation was observed between the number of eosinophils and that of Th17 cells in the small intestine of wild-type mice. In addition, small intestinal eosinophils suppressed the in vitro differentiation of Th17 cells, as well as IL-17 production by small intestinal CD4+ T cells. Unlike other small intestinal immune cells or circulating eosinophils, we found that small intestinal eosinophils have a unique ability to constitutively secrete high levels of IL-1 receptor antagonist (IL-1Ra), a natural inhibitor of IL-1β. Moreover, small intestinal eosinophils isolated from IL-1Ra−deficient mice failed to suppress Th17 cells. Collectively, our results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra." @default.
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- W2300366124 date "2016-03-07" @default.
- W2300366124 modified "2023-10-15" @default.
- W2300366124 title "Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist" @default.
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- W2300366124 doi "https://doi.org/10.1084/jem.20141388" @default.
- W2300366124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4821642" @default.
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