Matches in SemOpenAlex for { <https://semopenalex.org/work/W2300380496> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2300380496 endingPage "100" @default.
- W2300380496 startingPage "93" @default.
- W2300380496 abstract "The blocking effects of cilnidipine and other dihydropyridines on L-type cardiac Ca2+ channels (ICa,L) and N-type sympathetic Ca2+ channel currents (ICa,N) were studied using a whole-cell patch-clamp technique. At −80 mV, cilnidipine had little inhibitory effect below concentrations of 1 μM on ICa,L (IC50 value; 17 μM). However, 1 μM cilnidipine strongly shifted the steady-state inactivation curve of ICa,L toward negative potentials without changing the current–voltage relationship. Each action of cilnidipine was characterized by a high affinity for the inactivated channel in preference to the resting channel. The IC50 values of dihydropyridines for ICa,L were in the range between 0.01 and 10 μM, and those for ICa,N were between 3 and 30 μM. Cilnidipine had the strongest affinity for ICa,N among the dihydropyridines tested. These results suggest that cilnidipine did not cause hypotension-evoked tachycardia deficiency by depression of cardiac L-type channels but by sympathetic N-type channels blockade." @default.
- W2300380496 created "2016-06-24" @default.
- W2300380496 creator A5019621323 @default.
- W2300380496 creator A5031937425 @default.
- W2300380496 creator A5035629549 @default.
- W2300380496 creator A5052993188 @default.
- W2300380496 creator A5067610204 @default.
- W2300380496 date "1999-05-01" @default.
- W2300380496 modified "2023-09-27" @default.
- W2300380496 title "Selectivity of dihydropyridines for cardiac L-type and sympathetic N-type Ca2+ channels" @default.
- W2300380496 cites W1979679557 @default.
- W2300380496 cites W1985957556 @default.
- W2300380496 cites W2009667219 @default.
- W2300380496 cites W2010654277 @default.
- W2300380496 cites W2011765859 @default.
- W2300380496 cites W2018569696 @default.
- W2300380496 cites W2039898115 @default.
- W2300380496 cites W2050464131 @default.
- W2300380496 cites W2053559739 @default.
- W2300380496 cites W2074849101 @default.
- W2300380496 cites W2076778401 @default.
- W2300380496 cites W2086531600 @default.
- W2300380496 cites W2090981990 @default.
- W2300380496 cites W2091251248 @default.
- W2300380496 cites W2092805838 @default.
- W2300380496 cites W2113614111 @default.
- W2300380496 cites W2124467860 @default.
- W2300380496 cites W2145565753 @default.
- W2300380496 cites W2149361059 @default.
- W2300380496 cites W2318480619 @default.
- W2300380496 cites W4232071938 @default.
- W2300380496 cites W951092677 @default.
- W2300380496 doi "https://doi.org/10.1016/s0014-2999(99)00237-x" @default.
- W2300380496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10408255" @default.
- W2300380496 hasPublicationYear "1999" @default.
- W2300380496 type Work @default.
- W2300380496 sameAs 2300380496 @default.
- W2300380496 citedByCount "44" @default.
- W2300380496 countsByYear W23003804962012 @default.
- W2300380496 countsByYear W23003804962013 @default.
- W2300380496 countsByYear W23003804962014 @default.
- W2300380496 countsByYear W23003804962015 @default.
- W2300380496 countsByYear W23003804962016 @default.
- W2300380496 countsByYear W23003804962019 @default.
- W2300380496 countsByYear W23003804962022 @default.
- W2300380496 countsByYear W23003804962023 @default.
- W2300380496 crossrefType "journal-article" @default.
- W2300380496 hasAuthorship W2300380496A5019621323 @default.
- W2300380496 hasAuthorship W2300380496A5031937425 @default.
- W2300380496 hasAuthorship W2300380496A5035629549 @default.
- W2300380496 hasAuthorship W2300380496A5052993188 @default.
- W2300380496 hasAuthorship W2300380496A5067610204 @default.
- W2300380496 hasConcept C12554922 @default.
- W2300380496 hasConcept C126322002 @default.
- W2300380496 hasConcept C134018914 @default.
- W2300380496 hasConcept C147944092 @default.
- W2300380496 hasConcept C170493617 @default.
- W2300380496 hasConcept C185592680 @default.
- W2300380496 hasConcept C202751555 @default.
- W2300380496 hasConcept C2777752497 @default.
- W2300380496 hasConcept C2778468042 @default.
- W2300380496 hasConcept C55493867 @default.
- W2300380496 hasConcept C71924100 @default.
- W2300380496 hasConcept C86803240 @default.
- W2300380496 hasConcept C98274493 @default.
- W2300380496 hasConceptScore W2300380496C12554922 @default.
- W2300380496 hasConceptScore W2300380496C126322002 @default.
- W2300380496 hasConceptScore W2300380496C134018914 @default.
- W2300380496 hasConceptScore W2300380496C147944092 @default.
- W2300380496 hasConceptScore W2300380496C170493617 @default.
- W2300380496 hasConceptScore W2300380496C185592680 @default.
- W2300380496 hasConceptScore W2300380496C202751555 @default.
- W2300380496 hasConceptScore W2300380496C2777752497 @default.
- W2300380496 hasConceptScore W2300380496C2778468042 @default.
- W2300380496 hasConceptScore W2300380496C55493867 @default.
- W2300380496 hasConceptScore W2300380496C71924100 @default.
- W2300380496 hasConceptScore W2300380496C86803240 @default.
- W2300380496 hasConceptScore W2300380496C98274493 @default.
- W2300380496 hasIssue "1" @default.
- W2300380496 hasLocation W23003804961 @default.
- W2300380496 hasLocation W23003804962 @default.
- W2300380496 hasOpenAccess W2300380496 @default.
- W2300380496 hasPrimaryLocation W23003804961 @default.
- W2300380496 hasRelatedWork W1589702965 @default.
- W2300380496 hasRelatedWork W1983428644 @default.
- W2300380496 hasRelatedWork W1998497870 @default.
- W2300380496 hasRelatedWork W2077180960 @default.
- W2300380496 hasRelatedWork W2121464440 @default.
- W2300380496 hasRelatedWork W2133508058 @default.
- W2300380496 hasRelatedWork W2210134072 @default.
- W2300380496 hasRelatedWork W2352760229 @default.
- W2300380496 hasRelatedWork W4327613859 @default.
- W2300380496 hasRelatedWork W2050541809 @default.
- W2300380496 hasVolume "373" @default.
- W2300380496 isParatext "false" @default.
- W2300380496 isRetracted "false" @default.
- W2300380496 magId "2300380496" @default.
- W2300380496 workType "article" @default.