Matches in SemOpenAlex for { <https://semopenalex.org/work/W2300456867> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2300456867 abstract "OBJECTIVE: The aim of this study was to evaluate concentration of copper, iron, zinc and manganese in WD brain autopsy tissues and their association with WD phenotypic presentation. BACKGROUND: Wilson9s Disease (WD) is an inherited copper metabolism disorder with pathological copper tissue accumulation, mainly in liver and brain. Previous studies have shown that accumulation of other metals in the brain tissue occurs in numerous neurodegenerative disorders. However, until now this issue have not been quantitatively examined in WD. DESIGN/METHODS: The study material consisted of 17 brains (12 WD patients, 5 controls) obtained upon autopsy. Samples were taken from 4 different regions of each brain: frontal cortex, putamen, nucleus dentatus and pons. The copper, manganese and zinc levels were assessed using plasma mass spectrometry. Iron concentration was measured with atomic absorption spectroscopy. Clinical presentation of WD was considered hepatic or neuropsychiatric. RESULTS: Copper content was homogenously increased in all investigated structures of WD brains compared to controls (41.0±18.6 vs. 5.4±1.8 mg/g, p CONCLUSIONS: According to our findings, in the course of WD copper accumulate in different parts of the brain irrespectively of predominant phenotypic presentation. Zinc and manganese does not seem to be involved in the pathology. However, increased amounts of iron appear to accumulate in nucleus dentatus. We speculate that this effect may be due to diminished level of ceruloplasmin, but further studies are needed. Disclosure: Dr. Czlonkowska has received personal compensation in an editorial capacity for acting as journal editor for the Polish version of Neurology. Dr. Litwin has nothing to disclose. Dr. Gromadzka has nothing to disclose. Dr. Szpak has nothing to disclose. Dr. Bulska has nothing to disclose." @default.
- W2300456867 created "2016-06-24" @default.
- W2300456867 creator A5032814461 @default.
- W2300456867 creator A5060678024 @default.
- W2300456867 creator A5067303076 @default.
- W2300456867 creator A5073289723 @default.
- W2300456867 creator A5076088432 @default.
- W2300456867 date "2013-02-12" @default.
- W2300456867 modified "2023-09-25" @default.
- W2300456867 title "The Brain Metals Accumulation in Wilson's Disease (P03.061)" @default.
- W2300456867 hasPublicationYear "2013" @default.
- W2300456867 type Work @default.
- W2300456867 sameAs 2300456867 @default.
- W2300456867 citedByCount "0" @default.
- W2300456867 crossrefType "journal-article" @default.
- W2300456867 hasAuthorship W2300456867A5032814461 @default.
- W2300456867 hasAuthorship W2300456867A5060678024 @default.
- W2300456867 hasAuthorship W2300456867A5067303076 @default.
- W2300456867 hasAuthorship W2300456867A5073289723 @default.
- W2300456867 hasAuthorship W2300456867A5076088432 @default.
- W2300456867 hasConcept C126322002 @default.
- W2300456867 hasConcept C142724271 @default.
- W2300456867 hasConcept C178790620 @default.
- W2300456867 hasConcept C185592680 @default.
- W2300456867 hasConcept C207886595 @default.
- W2300456867 hasConcept C2776231509 @default.
- W2300456867 hasConcept C2777581567 @default.
- W2300456867 hasConcept C2779134260 @default.
- W2300456867 hasConcept C2779504383 @default.
- W2300456867 hasConcept C2779714222 @default.
- W2300456867 hasConcept C28452662 @default.
- W2300456867 hasConcept C2991729501 @default.
- W2300456867 hasConcept C528890316 @default.
- W2300456867 hasConcept C535196362 @default.
- W2300456867 hasConcept C544778455 @default.
- W2300456867 hasConcept C71924100 @default.
- W2300456867 hasConceptScore W2300456867C126322002 @default.
- W2300456867 hasConceptScore W2300456867C142724271 @default.
- W2300456867 hasConceptScore W2300456867C178790620 @default.
- W2300456867 hasConceptScore W2300456867C185592680 @default.
- W2300456867 hasConceptScore W2300456867C207886595 @default.
- W2300456867 hasConceptScore W2300456867C2776231509 @default.
- W2300456867 hasConceptScore W2300456867C2777581567 @default.
- W2300456867 hasConceptScore W2300456867C2779134260 @default.
- W2300456867 hasConceptScore W2300456867C2779504383 @default.
- W2300456867 hasConceptScore W2300456867C2779714222 @default.
- W2300456867 hasConceptScore W2300456867C28452662 @default.
- W2300456867 hasConceptScore W2300456867C2991729501 @default.
- W2300456867 hasConceptScore W2300456867C528890316 @default.
- W2300456867 hasConceptScore W2300456867C535196362 @default.
- W2300456867 hasConceptScore W2300456867C544778455 @default.
- W2300456867 hasConceptScore W2300456867C71924100 @default.
- W2300456867 hasLocation W23004568671 @default.
- W2300456867 hasOpenAccess W2300456867 @default.
- W2300456867 hasPrimaryLocation W23004568671 @default.
- W2300456867 hasRelatedWork W1965794600 @default.
- W2300456867 hasRelatedWork W1970504689 @default.
- W2300456867 hasRelatedWork W1981360849 @default.
- W2300456867 hasRelatedWork W2016033388 @default.
- W2300456867 hasRelatedWork W2040545684 @default.
- W2300456867 hasRelatedWork W2377390195 @default.
- W2300456867 hasRelatedWork W2755408424 @default.
- W2300456867 hasVolume "80" @default.
- W2300456867 isParatext "false" @default.
- W2300456867 isRetracted "false" @default.
- W2300456867 magId "2300456867" @default.
- W2300456867 workType "article" @default.