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- W2300515871 abstract "In an effort to establish new candidates with improved anticancer activity, we report here the synthesis of various series of 7H-indeno[2,1-c][1,5]-naphthyridines and novel 7H-indeno[2,1-c][1,5]-naphthyridine-7-ones and 7H-indeno[2,1-c][1,5]-naphthyridine-7-ols. Most of the products which were synthesized were able to inhibit Topoisomerase I activity. Moreover, in vitro testing demonstrated that a subset of the products exhibited a cytotoxic effect on cell lines derived from human breast cancer (BT 20), human lung adenocarcinoma (A 549), or human ovarian carcinoma (SKOV3)." @default.
- W2300515871 created "2016-06-24" @default.
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- W2300515871 date "2016-06-01" @default.
- W2300515871 modified "2023-10-17" @default.
- W2300515871 title "Synthesis and biological evaluation of indeno[1,5]naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity" @default.
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- W2300515871 doi "https://doi.org/10.1016/j.ejmech.2016.03.031" @default.
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