Matches in SemOpenAlex for { <https://semopenalex.org/work/W2300526711> ?p ?o ?g. }
- W2300526711 endingPage "90" @default.
- W2300526711 startingPage "69" @default.
- W2300526711 abstract "The mineralized structure of bone undergoes constant remodeling by the balanced actions of bone-producing osteoblasts and bone-resorbing osteoclasts (OCLs). Physiologic bone remodeling occurs in response to the body's need to respond to changes in electrolyte levels, or mechanical forces on bone. There are many pathological conditions, however, that cause an imbalance between bone production and resorption due to excessive OCL action that results in net bone loss. Situations involving chronic or acute inflammation are often associated with net bone loss, and research into understanding the mechanisms regulating this bone loss has led to the development of the field of osteoimmunology. It is now evident that the skeletal and immune systems are functionally linked and share common cells and signaling molecules. This review discusses the signaling system of immune cells and cytokines regulating aberrant OCL differentiation and activity. The role of these cells and cytokines in the bone loss occurring in periodontal disease (PD) (chronic inflammation) and orthodontic tooth movement (OTM) (acute inflammation) is then described. The review finishes with an exploration of the emerging role of Notch signaling in the development of the immune cells and OCLs that are involved in osteoimmunological bone loss and the research into Notch signaling in OTM and PD." @default.
- W2300526711 created "2016-06-24" @default.
- W2300526711 creator A5008566373 @default.
- W2300526711 date "2016-03-03" @default.
- W2300526711 modified "2023-10-18" @default.
- W2300526711 title "The osteoimmunology of alveolar bone loss" @default.
- W2300526711 cites W14274566 @default.
- W2300526711 cites W1489454155 @default.
- W2300526711 cites W1525531948 @default.
- W2300526711 cites W1534645474 @default.
- W2300526711 cites W1542406910 @default.
- W2300526711 cites W1545561369 @default.
- W2300526711 cites W1549053710 @default.
- W2300526711 cites W1567309370 @default.
- W2300526711 cites W1588586232 @default.
- W2300526711 cites W1593020674 @default.
- W2300526711 cites W1639854378 @default.
- W2300526711 cites W1650001464 @default.
- W2300526711 cites W1651300485 @default.
- W2300526711 cites W1677043489 @default.
- W2300526711 cites W1848259078 @default.
- W2300526711 cites W1852976765 @default.
- W2300526711 cites W1886623575 @default.
- W2300526711 cites W1891992064 @default.
- W2300526711 cites W1915518296 @default.
- W2300526711 cites W1925706324 @default.
- W2300526711 cites W1931719913 @default.
- W2300526711 cites W1942076196 @default.
- W2300526711 cites W1963138732 @default.
- W2300526711 cites W1963700437 @default.
- W2300526711 cites W1964794992 @default.
- W2300526711 cites W1967380744 @default.
- W2300526711 cites W1967742449 @default.
- W2300526711 cites W1967867385 @default.
- W2300526711 cites W1968141197 @default.
- W2300526711 cites W1969078493 @default.
- W2300526711 cites W1969179523 @default.
- W2300526711 cites W1969871258 @default.
- W2300526711 cites W1971033883 @default.
- W2300526711 cites W1972595917 @default.
- W2300526711 cites W1975587041 @default.
- W2300526711 cites W1976133234 @default.
- W2300526711 cites W1977668440 @default.
- W2300526711 cites W1978495122 @default.
- W2300526711 cites W1980212327 @default.
- W2300526711 cites W1980782312 @default.
- W2300526711 cites W1981819997 @default.
- W2300526711 cites W1982381891 @default.
- W2300526711 cites W1982395713 @default.
- W2300526711 cites W1983068219 @default.
- W2300526711 cites W1983454644 @default.
- W2300526711 cites W1984452675 @default.
- W2300526711 cites W1984631633 @default.
- W2300526711 cites W1985823049 @default.
- W2300526711 cites W1986952411 @default.
- W2300526711 cites W1987032872 @default.
- W2300526711 cites W1987162032 @default.
- W2300526711 cites W1990691928 @default.
- W2300526711 cites W1993419851 @default.
- W2300526711 cites W1994517874 @default.
- W2300526711 cites W1994756823 @default.
- W2300526711 cites W1997209485 @default.
- W2300526711 cites W1997504364 @default.
- W2300526711 cites W1997722036 @default.
- W2300526711 cites W1997966580 @default.
- W2300526711 cites W1999235557 @default.
- W2300526711 cites W1999729259 @default.
- W2300526711 cites W1999985403 @default.
- W2300526711 cites W2000647744 @default.
- W2300526711 cites W2000809028 @default.
- W2300526711 cites W2002753637 @default.
- W2300526711 cites W2003324119 @default.
- W2300526711 cites W2004186675 @default.
- W2300526711 cites W2004579907 @default.
- W2300526711 cites W2006128988 @default.
- W2300526711 cites W2006915486 @default.
- W2300526711 cites W2006950202 @default.
- W2300526711 cites W2007282300 @default.
- W2300526711 cites W2009045823 @default.
- W2300526711 cites W2011905697 @default.
- W2300526711 cites W2017302703 @default.
- W2300526711 cites W2017372504 @default.
- W2300526711 cites W2018544354 @default.
- W2300526711 cites W2018682447 @default.
- W2300526711 cites W2019007505 @default.
- W2300526711 cites W2022044375 @default.
- W2300526711 cites W2022538035 @default.
- W2300526711 cites W2023205404 @default.
- W2300526711 cites W2023245305 @default.
- W2300526711 cites W2024023085 @default.
- W2300526711 cites W2025128018 @default.
- W2300526711 cites W2027741344 @default.
- W2300526711 cites W2028077169 @default.
- W2300526711 cites W2028174709 @default.
- W2300526711 cites W2028275698 @default.
- W2300526711 cites W2028463911 @default.
- W2300526711 cites W2030075526 @default.
- W2300526711 cites W2030182984 @default.