FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2300566818> ?p ?o ?g. }

• W2300566818 endingPage "1647" @default.
• W2300566818 startingPage "1637" @default.
• W2300566818 abstract "Abstract Although proteolytic processing of pro-von Willebrand factor (pro-vWF) resulting in free propeptide and mature vWF is known to be initiated intracellularly, vWF released from endothelial cells may contain a high proportion of incompletely processed pro-vWF. Because pro-vWF is only rarely detectable in normal human plasma, we investigated whether extracellular processing of pro-vWF is possible. A recombinant preparation (rpvWF) containing both pro-vWF and mature vWF subunits was infused into 2 pigs and 1 dog with severe von Willebrand disease, 2 mice with a targeted disruption of the vWF gene, and 2 healthy baboons. Total vWF antigen (vWF:Ag), free propeptide, and pro-vWF were measured using enzyme-linked immunosorbent assay techniques in blood samples drawn before and after infusion. vWF:Ag increased promptly. No pro-vWF could be detected when the first postinfusion sample was drawn after 30 minutes (pigs) or 60 minutes (mice), but pro-vWF was detectable for short periods when postinfusion samples were drawn after 15 minutes (dog) or 5 minutes (baboons). In contrast, free propeptide was increased at the first timepoint measured, suggesting that it was generated from the pro-vWF in the rpvWF preparation. vWF multimers were analyzed in the rpvWF preparation and in plasma samples drawn before and after infusion of rpvWF using ultra-high resolution 3% agarose gels to allow separation of homo- and hetero-forms of the vWF polymers. Within 30 minutes after infusion in the pigs, 1 hour in the dog and the mice, and within 2 hours in the baboons, the multimer pattern had changed to that typically seen in mature vWF. These data indicate that propeptide cleavage from unprocessed vWF can occur extracellularly in the circulation. The enzyme or enzymes responsible for this cleavage in plasma remain to be identified." @default.
• W2300566818 created "2016-06-24" @default.
• W2300566818 creator A5002259817 @default.
• W2300566818 creator A5008512512 @default.
• W2300566818 creator A5010084173 @default.
• W2300566818 creator A5023083682 @default.
• W2300566818 creator A5025284576 @default.
• W2300566818 creator A5028900692 @default.
• W2300566818 creator A5030842926 @default.
• W2300566818 creator A5048575193 @default.
• W2300566818 creator A5057229444 @default.
• W2300566818 creator A5059307767 @default.
• W2300566818 creator A5059559356 @default.
• W2300566818 creator A5084177659 @default.
• W2300566818 creator A5085735532 @default.
• W2300566818 date "1999-09-01" @default.
• W2300566818 modified "2023-10-14" @default.
• W2300566818 title "Evidence for Extracellular Processing of Pro-von Willebrand Factor After Infusion in Animals With and Without Severe von Willebrand Disease" @default.
• W2300566818 cites W118880679 @default.
• W2300566818 cites W1511639574 @default.
• W2300566818 cites W1537955253 @default.
• W2300566818 cites W1563019217 @default.
• W2300566818 cites W1563799601 @default.
• W2300566818 cites W1570269678 @default.
• W2300566818 cites W1586559331 @default.
• W2300566818 cites W169867413 @default.
• W2300566818 cites W1721634089 @default.
• W2300566818 cites W174752904 @default.
• W2300566818 cites W1928894857 @default.
• W2300566818 cites W1965790897 @default.
• W2300566818 cites W1969984823 @default.
• W2300566818 cites W1974175370 @default.
• W2300566818 cites W1998279685 @default.
• W2300566818 cites W1999881321 @default.
• W2300566818 cites W2013366266 @default.
• W2300566818 cites W2019803025 @default.
• W2300566818 cites W2024467920 @default.
• W2300566818 cites W2040943601 @default.
• W2300566818 cites W2047280427 @default.
• W2300566818 cites W2050579858 @default.
• W2300566818 cites W2054657407 @default.
• W2300566818 cites W2056845211 @default.
• W2300566818 cites W206975662 @default.
• W2300566818 cites W2072033614 @default.
• W2300566818 cites W2077290326 @default.
• W2300566818 cites W2080604344 @default.
• W2300566818 cites W2081648532 @default.
• W2300566818 cites W2100837269 @default.
• W2300566818 cites W2108868109 @default.
• W2300566818 cites W2121859722 @default.
• W2300566818 cites W2151077308 @default.
• W2300566818 cites W2175263209 @default.
• W2300566818 cites W221678615 @default.
• W2300566818 cites W2252676811 @default.
• W2300566818 cites W2270373849 @default.
• W2300566818 cites W2401795125 @default.
• W2300566818 cites W276645119 @default.
• W2300566818 cites W328832575 @default.
• W2300566818 cites W4229526059 @default.
• W2300566818 cites W4233069367 @default.
• W2300566818 cites W4299868476 @default.
• W2300566818 cites W59737231 @default.
• W2300566818 cites W93389695 @default.
• W2300566818 doi "https://doi.org/10.1182/blood.v94.5.1637" @default.
• W2300566818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10477688" @default.
• W2300566818 hasPublicationYear "1999" @default.
• W2300566818 type Work @default.
• W2300566818 sameAs 2300566818 @default.
• W2300566818 citedByCount "26" @default.
• W2300566818 countsByYear W23005668182013 @default.
• W2300566818 countsByYear W23005668182014 @default.
• W2300566818 countsByYear W23005668182015 @default.
• W2300566818 countsByYear W23005668182018 @default.
• W2300566818 crossrefType "journal-article" @default.
• W2300566818 hasAuthorship W2300566818A5002259817 @default.
• W2300566818 hasAuthorship W2300566818A5008512512 @default.
• W2300566818 hasAuthorship W2300566818A5010084173 @default.
• W2300566818 hasAuthorship W2300566818A5023083682 @default.
• W2300566818 hasAuthorship W2300566818A5025284576 @default.
• W2300566818 hasAuthorship W2300566818A5028900692 @default.
• W2300566818 hasAuthorship W2300566818A5030842926 @default.
• W2300566818 hasAuthorship W2300566818A5048575193 @default.
• W2300566818 hasAuthorship W2300566818A5057229444 @default.
• W2300566818 hasAuthorship W2300566818A5059307767 @default.
• W2300566818 hasAuthorship W2300566818A5059559356 @default.
• W2300566818 hasAuthorship W2300566818A5084177659 @default.
• W2300566818 hasAuthorship W2300566818A5085735532 @default.
• W2300566818 hasConcept C104317684 @default.
• W2300566818 hasConcept C126322002 @default.
• W2300566818 hasConcept C134018914 @default.
• W2300566818 hasConcept C153911025 @default.
• W2300566818 hasConcept C181199279 @default.
• W2300566818 hasConcept C185592680 @default.
• W2300566818 hasConcept C203014093 @default.
• W2300566818 hasConcept C2778780528 @default.
• W2300566818 hasConcept C2779394231 @default.
• W2300566818 hasConcept C40767141 @default.
• W2300566818 hasConcept C55493867 @default.

• next