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- W2300595118 abstract "Modulation of the immune response with anti-lymphocyte (L) monoclonal antibody (Ab) is a promising method for prevention of rejection. The authors examined the biodistribution of various types of anti L Abs in order to better define their mode of action. Mouse Ab against (1) all T Ls (Pan-T-Ab) and (2) helper T Ls (HT-Ab) were labeled with I-131 or In-111-DTPA. The Abs were injected separately into rats and their distribution compared with Ls prelabeled in vitro with In-111-oxine or In-111-DTPA-Ab. The biodistribution of Pan-T-Ab labeled with I-131 and In-111 was similar. At 2 hrs the mean% Id/g in spleen was 8.1 +- 0.3%, in lymph nodes 3.5 +- 0.4%, and in bone marrow (BM) 3.0 +- 0.1%. Localization in the thymus was low (0.1 +- 0.0%). At 24 hrs there was a rise in BM activity to 10.0 +- 0.9%. The distribution of L labeled with In-111-DTPA-Ab differed from that of L labeled with In-111-oxine in that with the latter lymphoid localization was higher and BM activity decreased with time. The biodistribution of HT-Ab labeled with I-131 and In-111 also was similar but differed from that of labeled Pan-T-Ab in that there was less concentration in lymphoid organs and littlemore » activity in the body by 24 hrs, a pattern previously observed to occur with cytolysis. These results suggest that (1) HT-Ab is toxic to Ls and can be used for selective HT-L depletion; (2) Pan-T-Ab is not toxic to L but could be useful in selective lymphoid ablation if labeled with a beta-emitter; and (3) the thymus is unaffected by anti L Abs and thymectomy may be necessary to achieve optimal anti rejection treatment with anti L Abs.« less" @default.
- W2300595118 created "2016-06-24" @default.
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- W2300595118 date "1984-01-01" @default.
- W2300595118 modified "2023-09-23" @default.
- W2300595118 title "The biodistribution of radiolabeled anti-lymphocyte monoclonal antibody in the rat" @default.
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