Matches in SemOpenAlex for { <https://semopenalex.org/work/W2300635504> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2300635504 endingPage "2799" @default.
- W2300635504 startingPage "2795" @default.
- W2300635504 abstract "Conventional wisdom argues against inbreeding, to maintain hybrid vigor and increase MHC diversity in response to pathogens. A recent report from the laboratory of Sing-Sing Way uses a mouse model to test a hypothesis put forward by Ray D. Owen more than 60 years ago: that a certain amount of inbreeding is a good thing. Owen proposed that antigens not inherited from the mother (noninherited maternal antigens), when replicated on the mate of the daughter, could protect the latter's developing child from fetal wastage due to immune attack during her pregnancy. Kinder et al use elegant mouse breeding models and MHC class II peptide tetramers to show that Owen's hypothesis, based only on humoral (anti-Rh IgG) data and a small sample size, was indeed correct. The mediators of this cross-generational protection turn out to be a special kind of Foxp3+ T regulatory cell, the development of which requires the persistence of maternal microchimerism into adulthood. The implications of this discovery for the role of microchimerism in tolerance to transplants are discussed." @default.
- W2300635504 created "2016-06-24" @default.
- W2300635504 creator A5008871183 @default.
- W2300635504 date "2016-10-01" @default.
- W2300635504 modified "2023-10-14" @default.
- W2300635504 title "Clinical Implications of Basic Science Discoveries: Microchimerism Finds a Major Role in Reproductive Success; but Does It Also Contribute to Transplant Success?" @default.
- W2300635504 cites W1690408836 @default.
- W2300635504 cites W1966957841 @default.
- W2300635504 cites W1976289976 @default.
- W2300635504 cites W1986793996 @default.
- W2300635504 cites W2024234239 @default.
- W2300635504 cites W2031691018 @default.
- W2300635504 cites W2039801541 @default.
- W2300635504 cites W2057053586 @default.
- W2300635504 cites W2058938835 @default.
- W2300635504 cites W2063576731 @default.
- W2300635504 cites W2072066004 @default.
- W2300635504 cites W2072509185 @default.
- W2300635504 cites W2073696038 @default.
- W2300635504 cites W2076979848 @default.
- W2300635504 cites W2083102356 @default.
- W2300635504 cites W2088201271 @default.
- W2300635504 cites W2104959557 @default.
- W2300635504 cites W2144935590 @default.
- W2300635504 cites W2160032371 @default.
- W2300635504 cites W2169069585 @default.
- W2300635504 cites W2267140840 @default.
- W2300635504 cites W2299443261 @default.
- W2300635504 cites W2302493455 @default.
- W2300635504 cites W2323349969 @default.
- W2300635504 cites W2510862217 @default.
- W2300635504 doi "https://doi.org/10.1111/ajt.13785" @default.
- W2300635504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26988284" @default.
- W2300635504 hasPublicationYear "2016" @default.
- W2300635504 type Work @default.
- W2300635504 sameAs 2300635504 @default.
- W2300635504 citedByCount "2" @default.
- W2300635504 countsByYear W23006355042019 @default.
- W2300635504 countsByYear W23006355042021 @default.
- W2300635504 crossrefType "journal-article" @default.
- W2300635504 hasAuthorship W2300635504A5008871183 @default.
- W2300635504 hasBestOaLocation W23006355041 @default.
- W2300635504 hasConcept C147483822 @default.
- W2300635504 hasConcept C162834538 @default.
- W2300635504 hasConcept C172680121 @default.
- W2300635504 hasConcept C188280979 @default.
- W2300635504 hasConcept C203014093 @default.
- W2300635504 hasConcept C207936829 @default.
- W2300635504 hasConcept C2777782036 @default.
- W2300635504 hasConcept C2779234561 @default.
- W2300635504 hasConcept C2779727006 @default.
- W2300635504 hasConcept C2908647359 @default.
- W2300635504 hasConcept C54355233 @default.
- W2300635504 hasConcept C71924100 @default.
- W2300635504 hasConcept C78458016 @default.
- W2300635504 hasConcept C86803240 @default.
- W2300635504 hasConcept C8891405 @default.
- W2300635504 hasConcept C99454951 @default.
- W2300635504 hasConceptScore W2300635504C147483822 @default.
- W2300635504 hasConceptScore W2300635504C162834538 @default.
- W2300635504 hasConceptScore W2300635504C172680121 @default.
- W2300635504 hasConceptScore W2300635504C188280979 @default.
- W2300635504 hasConceptScore W2300635504C203014093 @default.
- W2300635504 hasConceptScore W2300635504C207936829 @default.
- W2300635504 hasConceptScore W2300635504C2777782036 @default.
- W2300635504 hasConceptScore W2300635504C2779234561 @default.
- W2300635504 hasConceptScore W2300635504C2779727006 @default.
- W2300635504 hasConceptScore W2300635504C2908647359 @default.
- W2300635504 hasConceptScore W2300635504C54355233 @default.
- W2300635504 hasConceptScore W2300635504C71924100 @default.
- W2300635504 hasConceptScore W2300635504C78458016 @default.
- W2300635504 hasConceptScore W2300635504C86803240 @default.
- W2300635504 hasConceptScore W2300635504C8891405 @default.
- W2300635504 hasConceptScore W2300635504C99454951 @default.
- W2300635504 hasIssue "10" @default.
- W2300635504 hasLocation W23006355041 @default.
- W2300635504 hasLocation W23006355042 @default.
- W2300635504 hasOpenAccess W2300635504 @default.
- W2300635504 hasPrimaryLocation W23006355041 @default.
- W2300635504 hasRelatedWork W1217682272 @default.
- W2300635504 hasRelatedWork W2000517384 @default.
- W2300635504 hasRelatedWork W2001055320 @default.
- W2300635504 hasRelatedWork W2031356189 @default.
- W2300635504 hasRelatedWork W2149871822 @default.
- W2300635504 hasRelatedWork W2220102944 @default.
- W2300635504 hasRelatedWork W2409441623 @default.
- W2300635504 hasRelatedWork W2426708948 @default.
- W2300635504 hasRelatedWork W3018986011 @default.
- W2300635504 hasRelatedWork W402048087 @default.
- W2300635504 hasVolume "16" @default.
- W2300635504 isParatext "false" @default.
- W2300635504 isRetracted "false" @default.
- W2300635504 magId "2300635504" @default.
- W2300635504 workType "article" @default.