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- W2300837561 abstract "Protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin signaling, has served as a potential drug target for the treatment of type 2 diabetes. The MeOH extracts of twenty-nine medicinal plants, traditionally used in Vietnam as anti-diabetes agents, were investigated for PTP1B inhibitory activity in vitro. The results indicated that, most materials showed moderate to strong inhibitory activity with IC50 values ranging from 3.4 μg/mL to 35.1 μg/mL; meanwhile, eleven extracts (37.9%) could demonstrate PTP1B activity with IC50 values less than 15.5 μg/mL; sixteen extracts (55.2%) could demonstrate PTP1B activity with IC50 values ranging from 15.5 μg/mL to 35.1 μg/mL. The study may provide a proof, at least in a part, for the ethno-medical use in diabetes disease of these plants." @default.
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- W2300837561 date "2010-01-01" @default.
- W2300837561 modified "2023-09-26" @default.
- W2300837561 title "Screening of Protein Tyrosine Phosphatase 1B Inhibitory Activity from Some Vietnamese Medicinal Plants" @default.
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