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- W2300873060 endingPage "113" @default.
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- W2300873060 abstract "Intracellular Ca2+ (Ca1) dynamics plays an important role in the initiation and maintenance of atrial fibrillation (AF). Specific intrinsic action potential properties and pacemaking cells within the pulmonary veins (PVs) contribute to PV arrhythmogenicity. Simultaneous sympathovagal activation could increase Cai and shorten action potential duration at the same time, resulting in triggered activity from the PVs and initiating AF. The maintenance of AF depends on both the triggered activity within the PVs and reentrant wave fronts in the atria and in the PVs. The reentrant wave fronts that conduct from the atria into the PVs increase the activation rate in the PVs, hence increasing Cai accumulation and triggered discharges. In the meantime, the wave fronts that conduct from the PVs into the atria may add complexities to atrial activations and support further wave break and reentry. Overload of Cai is likely to be a primary factor mediating both the short-term and chronic electrophysiological remodeling associated with AF.KeywordsAtriumCalciumDynamicsIon channelsFibrillationMappingTriggered activity" @default.
- W2300873060 created "2016-06-24" @default.
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- W2300873060 date "2008-01-01" @default.
- W2300873060 modified "2023-09-23" @default.
- W2300873060 title "Intracellular Calcium Dynamics and Atrial Fibrillation" @default.
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- W2300873060 doi "https://doi.org/10.1007/978-1-59745-163-5_8" @default.
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