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- W2300892736 abstract "Cylindrical rings made of silicone rubber, which were impregnated with medroxyprogesterone acetate were placed in the vaginas of 3 regularly menstruating subjects on the first cycle day. During the 28 days that these rings were in place, there was continuous systemic absorption of the progestogen as determined by elevation of the BBT (basal body temperature), shift in maturation index, abolition of the midcycle LH peak, and alteration of the endometrial histology. Following removal of the rings, there was a prompt termination of drug activity as determined by withdrawal bleeding and a fall in the BBT. Presumptive evidence of ovulation followed shortly thereafter. It is hoped to develop this method of administering a progestational steroid for the purpose of family planning. Cylindrical rings made of silicone rubber, which were impregnated with medroxyprogesterone acetate were placed in the vaginas of 3 regularly menstruating subjects on the first cycle day. During the 28 days that these rings were in place, there was continuous systemic absorption of the progestogen as determined by elevation of the BBT (basal body temperature), shift in maturation index, abolition of the midcycle LH peak, and alteration of the endometrial histology. Following removal of the rings, there was a prompt termination of drug activity as determined by withdrawal bleeding and a fall in the BBT. Presumptive evidence of ovulation followed shortly thereafter. It is hoped to develop this method of administering a progestational steroid for the purpose of family planning." @default.
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- W2300892736 date "1970-05-01" @default.
- W2300892736 modified "2023-10-15" @default.
- W2300892736 title "Contraception by means of a Silastic vaginal ring impregnated with medroxyprogesterone acetate" @default.
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- W2300892736 doi "https://doi.org/10.1016/s0002-9378(16)33897-2" @default.
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