Matches in SemOpenAlex for { <https://semopenalex.org/work/W2300912716> ?p ?o ?g. }
- W2300912716 endingPage "e0150792" @default.
- W2300912716 startingPage "e0150792" @default.
- W2300912716 abstract "The innate immune system critically shapes diabetogenic adaptive immunity during type 1 diabetes (T1D) pathogenesis. While the role of tissue-infiltrating monocyte-derived macrophages in T1D is well established, the role of their tissue-resident counterparts remains undefined. We now demonstrate that islet resident macrophages (IRMs) from non-autoimmune mice have an immunoregulatory phenotype and powerfully induce FoxP3+ Tregs in vitro. The immunoregulatory phenotype and function of IRMs is compromised by TLR4 activation in vitro. Moreover, as T1D approaches in NOD mice, the immunoregulatory phenotype of IRMs is diminished as is their relative abundance compared to immunostimulatory DCs. Our findings suggest that maintenance of IRM abundance and their immunoregulatory phenotype may constitute a novel therapeutic strategy to prevent and/or cure T1D." @default.
- W2300912716 created "2016-06-24" @default.
- W2300912716 creator A5006590967 @default.
- W2300912716 creator A5020454814 @default.
- W2300912716 creator A5028104289 @default.
- W2300912716 creator A5031332684 @default.
- W2300912716 creator A5034249761 @default.
- W2300912716 creator A5042116545 @default.
- W2300912716 creator A5055441364 @default.
- W2300912716 creator A5069765168 @default.
- W2300912716 creator A5073246188 @default.
- W2300912716 creator A5085873910 @default.
- W2300912716 date "2016-03-04" @default.
- W2300912716 modified "2023-09-27" @default.
- W2300912716 title "Contrasting Roles of Islet Resident Immunoregulatory Macrophages and Dendritic Cells in Experimental Autoimmune Type 1 Diabetes" @default.
- W2300912716 cites W1499727701 @default.
- W2300912716 cites W1521026317 @default.
- W2300912716 cites W1933840867 @default.
- W2300912716 cites W1954497589 @default.
- W2300912716 cites W1973433801 @default.
- W2300912716 cites W1980849466 @default.
- W2300912716 cites W1983072380 @default.
- W2300912716 cites W1988250203 @default.
- W2300912716 cites W2016992811 @default.
- W2300912716 cites W2019954526 @default.
- W2300912716 cites W2024235284 @default.
- W2300912716 cites W2026578487 @default.
- W2300912716 cites W2027424073 @default.
- W2300912716 cites W2058593952 @default.
- W2300912716 cites W2061265562 @default.
- W2300912716 cites W2062572904 @default.
- W2300912716 cites W2070631889 @default.
- W2300912716 cites W2074340664 @default.
- W2300912716 cites W2078158773 @default.
- W2300912716 cites W2089964497 @default.
- W2300912716 cites W2098906780 @default.
- W2300912716 cites W2106190040 @default.
- W2300912716 cites W2109461990 @default.
- W2300912716 cites W2111740348 @default.
- W2300912716 cites W2114796458 @default.
- W2300912716 cites W2121165599 @default.
- W2300912716 cites W2131124022 @default.
- W2300912716 cites W2138307745 @default.
- W2300912716 cites W2138762519 @default.
- W2300912716 cites W2142242761 @default.
- W2300912716 cites W2143095313 @default.
- W2300912716 cites W2157202664 @default.
- W2300912716 cites W2157832975 @default.
- W2300912716 cites W2164345507 @default.
- W2300912716 cites W2170324175 @default.
- W2300912716 doi "https://doi.org/10.1371/journal.pone.0150792" @default.
- W2300912716 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4778921" @default.
- W2300912716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26943809" @default.
- W2300912716 hasPublicationYear "2016" @default.
- W2300912716 type Work @default.
- W2300912716 sameAs 2300912716 @default.
- W2300912716 citedByCount "11" @default.
- W2300912716 countsByYear W23009127162016 @default.
- W2300912716 countsByYear W23009127162017 @default.
- W2300912716 countsByYear W23009127162018 @default.
- W2300912716 countsByYear W23009127162019 @default.
- W2300912716 countsByYear W23009127162020 @default.
- W2300912716 countsByYear W23009127162021 @default.
- W2300912716 countsByYear W23009127162022 @default.
- W2300912716 countsByYear W23009127162023 @default.
- W2300912716 crossrefType "journal-article" @default.
- W2300912716 hasAuthorship W2300912716A5006590967 @default.
- W2300912716 hasAuthorship W2300912716A5020454814 @default.
- W2300912716 hasAuthorship W2300912716A5028104289 @default.
- W2300912716 hasAuthorship W2300912716A5031332684 @default.
- W2300912716 hasAuthorship W2300912716A5034249761 @default.
- W2300912716 hasAuthorship W2300912716A5042116545 @default.
- W2300912716 hasAuthorship W2300912716A5055441364 @default.
- W2300912716 hasAuthorship W2300912716A5069765168 @default.
- W2300912716 hasAuthorship W2300912716A5073246188 @default.
- W2300912716 hasAuthorship W2300912716A5085873910 @default.
- W2300912716 hasBestOaLocation W23009127161 @default.
- W2300912716 hasConcept C104317684 @default.
- W2300912716 hasConcept C127716648 @default.
- W2300912716 hasConcept C134018914 @default.
- W2300912716 hasConcept C136449434 @default.
- W2300912716 hasConcept C165220095 @default.
- W2300912716 hasConcept C193419808 @default.
- W2300912716 hasConcept C202751555 @default.
- W2300912716 hasConcept C203014093 @default.
- W2300912716 hasConcept C2778013207 @default.
- W2300912716 hasConcept C2779244956 @default.
- W2300912716 hasConcept C2779727006 @default.
- W2300912716 hasConcept C2780130043 @default.
- W2300912716 hasConcept C2781232474 @default.
- W2300912716 hasConcept C54355233 @default.
- W2300912716 hasConcept C555293320 @default.
- W2300912716 hasConcept C55851684 @default.
- W2300912716 hasConcept C86803240 @default.
- W2300912716 hasConcept C8891405 @default.
- W2300912716 hasConcept C95444343 @default.
- W2300912716 hasConceptScore W2300912716C104317684 @default.
- W2300912716 hasConceptScore W2300912716C127716648 @default.