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- W2300918723 abstract "The mode of action studies which investigated the potential of gestagens to inhibit ovulation are summarized chronologically from the 1st recognition of gestagenic effect of norethisterone in 1954 to present attempts at dealing with progestin-induced bleeding irregularities while maintaining contraceptive efficacy at the lowest possible dose and the simplest administration route. In the late 1960s a series of studies showed that daily low-dose (.5 mg) administration of progestin profoundly affected ovarian function and the effect produced was dose-dependent. The next study tested a .3-mg dose and the effects on ovarian function diminished. The 3rd study used a .1-mg dose and no signs of ovulation suppression or insufficient production of progesterone were apparent but the luteinizing hormone pattern was disturbed. Subsequent studies led to the following conclusion: the effects of gestagens on ovarian function occur in 3 dose-related groups. A high dose inhibits follicular development and no ovulation occurs. A moderate dose c follicles to develop but the gestagen inhibits positive feedback of estradiol and no ovulation takes place. Low doses cause mixed reactions. In some women ovulation is inhibited through positive feedback inhibition; however in many women ovulation does occur but the corpus luteum is insufficient." @default.
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- W2300918723 date "1978-01-01" @default.
- W2300918723 modified "2023-09-23" @default.
- W2300918723 title "Inhibition of ovulation by gestagens." @default.
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