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• W2300922079 endingPage "339" @default.
• W2300922079 startingPage "325" @default.
• W2300922079 abstract "Prevention of progression in neurological diseases, particularly in multiple sclerosis (MS) but also in neurodegenerative diseases, remains a significant challenge. MS patients switch from a relapsing-remitting to a progressive disease course, but it is not understood why and how this conversion occurs and why some patients never experience disease progression. Do aging and accumulation of neuronal damage induce progression, or do cognitive symptoms and accelerated grey matter (GM) atrophy point to distinct processes affecting networks? This review weighs accepted dogma against real data on the secondary progressive phase of the disease, highlighting current challenges in this important field and directions towards development of treatment strategies to slow or prevent progression of disability." @default.
• W2300922079 created "2016-06-24" @default.
• W2300922079 creator A5034957456 @default.
• W2300922079 creator A5060520647 @default.
• W2300922079 creator A5073011666 @default.
• W2300922079 creator A5083000991 @default.
• W2300922079 date "2016-05-01" @default.
• W2300922079 modified "2023-10-13" @default.
• W2300922079 title "Secondary Progression in Multiple Sclerosis: Neuronal Exhaustion or Distinct Pathology?" @default.
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