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- W2300924154 abstract "Background: XueZhiKang (XZK) is a pharmaceutical grade botanical product extracted from red yeast rice that has shown lipid-lowering efficacy and cardiovascular benefits in randomized, double-blind, placebo-controlled studies conducted outside the US. The goal of the present study was to evaluate the lipid lowering efficacy of XZK in patients in both the US and China. Methods: A double-blind, randomized, placebo-controlled, parallel group study with 116 randomized patients was conducted at 15 sites in the US and China. Inclusion criteria included a fasting low density lipoprotein cholesterol (LDL-C) level ≥ 160 but Results: The mean percentage decrease from baseline to week 12 on LDL-C levels (primary efficacy variable) was 26.8% in the 1200 mg/day group (from 177.4±29.8 to 128.6±29.8) and 27.0% in the 2400 mg/day group (from 175.7±25.2 to 125.7±26.7) in the intent-to-treat population with last observation carried forward. The placebo group showed a 0.8% increase in LDL-C level (from 174.3±23.1 to 174.9±26.0), resulting in highly significant (P Conclusions: This study demonstrated that XZK has significant lipid lowering efficacy in dyslipidemic patients and a favorable safety profile with similar results observed in patients enrolled in the US and China. Treatment with XZK appears safe and well tolerated. Future larger and longer studies are indicated to expand the efficacy and safety data of this natural product." @default.
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- W2300924154 date "2013-11-26" @default.
- W2300924154 modified "2023-09-27" @default.
- W2300924154 title "Abstract 11306: Red Yeast Rice Extract Shows Equivalency to Statins" @default.
- W2300924154 hasPublicationYear "2013" @default.
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