Matches in SemOpenAlex for { <https://semopenalex.org/work/W2300933413> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2300933413 abstract "Introduction Altered nutritional environment during intrauterine life may permanently affect tissue homeostasis of the fetus that can increase susceptibility of offspring to the development of disease in later life. Intrahepatic cholestasis of pregnancy (ICP) is a liver-specific disease of pregnancy that is characterised by increased bile acid (BA) levels in the maternal serum.Aim We aimed to establish the effects of exposure of the fetus to increased BA levels as a result of maternal cholestasis in the mouse.Method C57BL/6 mice were used for our studies (six mice/group). Cholestatic pregnancy was achieved with addition of 0.5% of cholic acid (CA) in the standard diet (ERD) 1 week before mating and up to day 18 of gestation when animals sacrificed. Biochemical measurements and gene and protein expression analyses took place in the maternal and fetal serum as well as maternal liver, fetal liver and placenta.Results Consistent with a cholestatic profile, fetuses from CA-fed mothers were characterised by raised BA levels in the serum (p<0.05). Also, the hepatic BA receptor, Fxr, was activated as indicated by alterations in its target genes (reduced Cyp7a1, increased Shp and Bsep). As a result of cholestasis, fetal hepatic cholesterol and fatty acid biosynthesis were induced as proved by up-regulation of Srebp2, Srebp1c, Hmgcr and Fas (p<0.05). Moreover, fetal hepatic cholesterol and triglycerides were increased relative to the levels of fetuses of ERD-fed mothers. Comparison between the placentas of ERD- vs CA-fed mothers revealed that CA-fed placentas had increased expression levels of lipogenic-related genes such as Adrp, Ldlr and Acat-2 (p<0.05), accompanied by raised placental cholesterol and decreased ApoB (p<0.05).Conclusion Cholestatic pregnancy leads to fetal cholestasis and increased hepatic cholesterol and fatty acid biosynthesis. The placental gene expression and biochemical profile imply that cholesterol accumulates in placenta instead of crossing into the fetal environment. Therefore, increased fetal hepatic cholesterol and fatty acid biosynthesis could be an adaptive mechanism of the fetus to fulfil their developmental nutritional demands. This may have adverse effects in later life of the offspring." @default.
- W2300933413 created "2016-06-24" @default.
- W2300933413 creator A5020074661 @default.
- W2300933413 creator A5027432256 @default.
- W2300933413 creator A5077072910 @default.
- W2300933413 creator A5077180416 @default.
- W2300933413 creator A5090608281 @default.
- W2300933413 date "2010-09-01" @default.
- W2300933413 modified "2023-09-23" @default.
- W2300933413 title "P42 Cholestatic pregnancy alters cholesterol and lipid transport to the fetal circulation, affecting lipid metabolism of the fetus" @default.
- W2300933413 doi "https://doi.org/10.1136/gut.2010.223362.68" @default.
- W2300933413 hasPublicationYear "2010" @default.
- W2300933413 type Work @default.
- W2300933413 sameAs 2300933413 @default.
- W2300933413 citedByCount "0" @default.
- W2300933413 crossrefType "journal-article" @default.
- W2300933413 hasAuthorship W2300933413A5020074661 @default.
- W2300933413 hasAuthorship W2300933413A5027432256 @default.
- W2300933413 hasAuthorship W2300933413A5077072910 @default.
- W2300933413 hasAuthorship W2300933413A5077180416 @default.
- W2300933413 hasAuthorship W2300933413A5090608281 @default.
- W2300933413 hasConcept C112672928 @default.
- W2300933413 hasConcept C126322002 @default.
- W2300933413 hasConcept C134018914 @default.
- W2300933413 hasConcept C172680121 @default.
- W2300933413 hasConcept C2775900799 @default.
- W2300933413 hasConcept C2776953305 @default.
- W2300933413 hasConcept C2778163477 @default.
- W2300933413 hasConcept C2778593092 @default.
- W2300933413 hasConcept C2778620825 @default.
- W2300933413 hasConcept C2779224579 @default.
- W2300933413 hasConcept C2779234561 @default.
- W2300933413 hasConcept C2779399885 @default.
- W2300933413 hasConcept C2779753670 @default.
- W2300933413 hasConcept C4733338 @default.
- W2300933413 hasConcept C54355233 @default.
- W2300933413 hasConcept C71924100 @default.
- W2300933413 hasConcept C86803240 @default.
- W2300933413 hasConceptScore W2300933413C112672928 @default.
- W2300933413 hasConceptScore W2300933413C126322002 @default.
- W2300933413 hasConceptScore W2300933413C134018914 @default.
- W2300933413 hasConceptScore W2300933413C172680121 @default.
- W2300933413 hasConceptScore W2300933413C2775900799 @default.
- W2300933413 hasConceptScore W2300933413C2776953305 @default.
- W2300933413 hasConceptScore W2300933413C2778163477 @default.
- W2300933413 hasConceptScore W2300933413C2778593092 @default.
- W2300933413 hasConceptScore W2300933413C2778620825 @default.
- W2300933413 hasConceptScore W2300933413C2779224579 @default.
- W2300933413 hasConceptScore W2300933413C2779234561 @default.
- W2300933413 hasConceptScore W2300933413C2779399885 @default.
- W2300933413 hasConceptScore W2300933413C2779753670 @default.
- W2300933413 hasConceptScore W2300933413C4733338 @default.
- W2300933413 hasConceptScore W2300933413C54355233 @default.
- W2300933413 hasConceptScore W2300933413C71924100 @default.
- W2300933413 hasConceptScore W2300933413C86803240 @default.
- W2300933413 hasLocation W23009334131 @default.
- W2300933413 hasOpenAccess W2300933413 @default.
- W2300933413 hasPrimaryLocation W23009334131 @default.
- W2300933413 hasRelatedWork W1550471667 @default.
- W2300933413 hasRelatedWork W2024334265 @default.
- W2300933413 hasRelatedWork W2027137959 @default.
- W2300933413 hasRelatedWork W2062381366 @default.
- W2300933413 hasRelatedWork W2088591813 @default.
- W2300933413 hasRelatedWork W2096031169 @default.
- W2300933413 hasRelatedWork W2096641459 @default.
- W2300933413 hasRelatedWork W2117108874 @default.
- W2300933413 hasRelatedWork W2352828122 @default.
- W2300933413 hasRelatedWork W2372296818 @default.
- W2300933413 hasRelatedWork W2406353319 @default.
- W2300933413 hasRelatedWork W2407530499 @default.
- W2300933413 hasRelatedWork W2462196004 @default.
- W2300933413 hasRelatedWork W2744361823 @default.
- W2300933413 hasRelatedWork W2981862071 @default.
- W2300933413 hasRelatedWork W2985788228 @default.
- W2300933413 hasRelatedWork W3022566786 @default.
- W2300933413 hasRelatedWork W3160845095 @default.
- W2300933413 hasRelatedWork W3201810860 @default.
- W2300933413 hasRelatedWork W59704765 @default.
- W2300933413 hasVolume "59" @default.
- W2300933413 isParatext "false" @default.
- W2300933413 isRetracted "false" @default.
- W2300933413 magId "2300933413" @default.
- W2300933413 workType "article" @default.