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- W2300961054 abstract "Lactoferrin (Lf) is a nonheme iron-binding glycoprotein strongly expressed in human and bovine milk and it plays many functions during infancy such as iron homeostasis and defense against microorganisms. In humans, Lf is mainly expressed in mucosal epithelial and immune cells. Growing evidence suggests multiple physiological roles for Lf after weaning.The aim of this review is to highlight the recent advances concerning multifunctional Lf activities.First, we will provide an overview of the mechanisms related to Lf intrinsic synthesis or intestinal absorption as well as its interaction with a wide spectrum of mammalian receptors and distribution in organs and cell types. Second, we will discuss the large variety of its physiological functions such as iron homeostasis, transportation, immune regulation, oxidative stress, inflammation, and apoptosis while specifying the mechanisms of action. Third, we will focus on its recent physiopathology implication in metabolic disorders, including obesity, type 2 diabetes, and cardiovascular diseases. Additional efforts are necessary before suggesting the potential use of Lf as a diagnostic marker or as a therapeutic tool.The main sources of Lf in human cardiometabolic disorders should be clarified to identify new perspectives for future research and develop new strategies using Lf in therapeutics. Antioxid. Redox Signal. 24, 813-836." @default.
- W2300961054 created "2016-06-24" @default.
- W2300961054 creator A5000579424 @default.
- W2300961054 creator A5006389093 @default.
- W2300961054 creator A5013914127 @default.
- W2300961054 creator A5020808506 @default.
- W2300961054 date "2016-05-10" @default.
- W2300961054 modified "2023-10-03" @default.
- W2300961054 title "Lactoferrin, a Pleiotropic Protein in Health and Disease" @default.
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