Matches in SemOpenAlex for { <https://semopenalex.org/work/W2300967417> ?p ?o ?g. }
- W2300967417 endingPage "199" @default.
- W2300967417 startingPage "193" @default.
- W2300967417 abstract "Abstract Increased activity of the renin-angiotensin-aldosterone system (RAAS) plays a significant role in the development and progression of various cardio-metabolic diseases, such as hypertension, atherosclerosis and heart failure. Aliskiren is the newest antihypertensive drug and the first orally active direct renin inhibitor to become available for clinical use. This study investigated the acute and direct effects of Aliskiren on different parameters of oxidative stress on isolated rat heart. The hearts of male Wistar albino rats (n = 24, 8 per experimental group, age 8 weeks, body mass 180–200 g), were excised and retrogradely perfused according to the Langendorfftechnique at a gradually increasing perfusion pressure (40-120 cmH 2 O). Markers of oxidative stress (NO 2 − , TBARS, H 2 O 2 and O 2 − ) were measured spectrophotometrically after perfusion with three different concentrations of Aliskiren (0.1 μM, 1 μM, and 10 μM). The results demonstrated possible dose-dependent cardioprotective properties of Aliskiren, particularly with higher CPP. Lipid peroxidation (TBARS) levels decreased with the highest dose of Aliskiren and higher CPP, and the same trend was observed in nitrite (NO 2 − ) and hydrogen peroxide (H 2 O 2 ) levels. These findings indicate that the acute effects of Aliskiren do not likely promote the production of reactive oxygen species upon higher pressure with the highest dose. Aliskiren may exert beneficial effects on oxidative stress biomarkers." @default.
- W2300967417 created "2016-06-24" @default.
- W2300967417 creator A5012228018 @default.
- W2300967417 creator A5012396249 @default.
- W2300967417 creator A5020200012 @default.
- W2300967417 creator A5020966018 @default.
- W2300967417 creator A5028192277 @default.
- W2300967417 creator A5039986595 @default.
- W2300967417 creator A5053356147 @default.
- W2300967417 creator A5054147525 @default.
- W2300967417 creator A5063394076 @default.
- W2300967417 creator A5083480110 @default.
- W2300967417 date "2015-09-01" @default.
- W2300967417 modified "2023-10-18" @default.
- W2300967417 title "Effects Of The Direct Renin Inhibitor Aliskiren On Oxidative Stress In Isolated Rat Heart" @default.
- W2300967417 cites W1699180303 @default.
- W2300967417 cites W1983310681 @default.
- W2300967417 cites W1984672931 @default.
- W2300967417 cites W1990802251 @default.
- W2300967417 cites W1992123948 @default.
- W2300967417 cites W1993767324 @default.
- W2300967417 cites W1994079702 @default.
- W2300967417 cites W1996319118 @default.
- W2300967417 cites W1999636472 @default.
- W2300967417 cites W2001527059 @default.
- W2300967417 cites W2013980075 @default.
- W2300967417 cites W2015183732 @default.
- W2300967417 cites W2015569360 @default.
- W2300967417 cites W2027008923 @default.
- W2300967417 cites W2034558621 @default.
- W2300967417 cites W2045281985 @default.
- W2300967417 cites W2047317161 @default.
- W2300967417 cites W2051411882 @default.
- W2300967417 cites W2075120792 @default.
- W2300967417 cites W2075354764 @default.
- W2300967417 cites W2085405235 @default.
- W2300967417 cites W2092685208 @default.
- W2300967417 cites W2106285152 @default.
- W2300967417 cites W2110489712 @default.
- W2300967417 cites W2131627750 @default.
- W2300967417 cites W2133452961 @default.
- W2300967417 cites W2142633078 @default.
- W2300967417 cites W2149330078 @default.
- W2300967417 cites W2151295696 @default.
- W2300967417 cites W2155732513 @default.
- W2300967417 cites W2155991679 @default.
- W2300967417 cites W2161015922 @default.
- W2300967417 cites W2171818587 @default.
- W2300967417 cites W61880999 @default.
- W2300967417 doi "https://doi.org/10.1515/sjecr-2015-0025" @default.
- W2300967417 hasPublicationYear "2015" @default.
- W2300967417 type Work @default.
- W2300967417 sameAs 2300967417 @default.
- W2300967417 citedByCount "0" @default.
- W2300967417 crossrefType "journal-article" @default.
- W2300967417 hasAuthorship W2300967417A5012228018 @default.
- W2300967417 hasAuthorship W2300967417A5012396249 @default.
- W2300967417 hasAuthorship W2300967417A5020200012 @default.
- W2300967417 hasAuthorship W2300967417A5020966018 @default.
- W2300967417 hasAuthorship W2300967417A5028192277 @default.
- W2300967417 hasAuthorship W2300967417A5039986595 @default.
- W2300967417 hasAuthorship W2300967417A5053356147 @default.
- W2300967417 hasAuthorship W2300967417A5054147525 @default.
- W2300967417 hasAuthorship W2300967417A5063394076 @default.
- W2300967417 hasAuthorship W2300967417A5083480110 @default.
- W2300967417 hasBestOaLocation W23009674171 @default.
- W2300967417 hasConcept C126322002 @default.
- W2300967417 hasConcept C134018914 @default.
- W2300967417 hasConcept C185592680 @default.
- W2300967417 hasConcept C198710026 @default.
- W2300967417 hasConcept C2776151105 @default.
- W2300967417 hasConcept C2777352226 @default.
- W2300967417 hasConcept C2777425892 @default.
- W2300967417 hasConcept C2779838083 @default.
- W2300967417 hasConcept C2780829032 @default.
- W2300967417 hasConcept C48349386 @default.
- W2300967417 hasConcept C55493867 @default.
- W2300967417 hasConcept C71924100 @default.
- W2300967417 hasConcept C84393581 @default.
- W2300967417 hasConcept C98274493 @default.
- W2300967417 hasConceptScore W2300967417C126322002 @default.
- W2300967417 hasConceptScore W2300967417C134018914 @default.
- W2300967417 hasConceptScore W2300967417C185592680 @default.
- W2300967417 hasConceptScore W2300967417C198710026 @default.
- W2300967417 hasConceptScore W2300967417C2776151105 @default.
- W2300967417 hasConceptScore W2300967417C2777352226 @default.
- W2300967417 hasConceptScore W2300967417C2777425892 @default.
- W2300967417 hasConceptScore W2300967417C2779838083 @default.
- W2300967417 hasConceptScore W2300967417C2780829032 @default.
- W2300967417 hasConceptScore W2300967417C48349386 @default.
- W2300967417 hasConceptScore W2300967417C55493867 @default.
- W2300967417 hasConceptScore W2300967417C71924100 @default.
- W2300967417 hasConceptScore W2300967417C84393581 @default.
- W2300967417 hasConceptScore W2300967417C98274493 @default.
- W2300967417 hasIssue "3" @default.
- W2300967417 hasLocation W23009674171 @default.
- W2300967417 hasOpenAccess W2300967417 @default.
- W2300967417 hasPrimaryLocation W23009674171 @default.