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• W2300975946 abstract "Tentative doses obtained using radiobiological and clinical data are proposed when 120 & 150 cGy bid is used for nasopharyngeal cancer (NPC) & non-small-cell lung cancer (NSCLC). Theoretical isoeffective doses are made into 2 tables using the LQ model and its related formalisms. The tables show the total dose needed using 120 or 150 cGy bid for an equivalent effect of a total dose of 5000, 6000, 7000, & 8000 cGy when given conventionally (200 Gy qd). α/β ratios of 2, 3, 4, and 10 Gy are used for the calculation. A repair half time of 2 hours is adopted and an incomplete repair factor of 0.125 is obtained for correction when a 6-h interfraction interval is used. For the primary tumour of NPC, 8000 cGy given 120 cGy bid is equivalent to 7000 cGy given conventionally for the normal tissue tolerance. When the clinical experience from the literature is considered, a dose of 7800 cGy is suggested. For the neck with and without metastatic nodes, doses of 7000-7500 and 5500-6000 cGy are considered reasonable. When 150 cGy bid is used, a dose of 7200 cGy is recommended for the primary tumour when clinical experience using 160 cGy bid is taken into account. As 7200 cGy given 150 cGy bid is completed 15 days shorter than 7000 cGy given 200 cGy qd, a further therapeutic gain equivalent to a dose of 900 cGy would be available. The dose to the spinal cord is recommended to be no more than 4800 cGy as clinical and experimental data have both shown a lack of increased tolerance of the cord when a small fraction size is given bid or tid. For a conventional dose of 6000-6500 cGy over 40-45 days given to NSCLC, a dose of 7000 cGy using 120 cGy bid is proposed considering the theoretical isoeffective dose and the experience reported. Less clinical literature is available regarding 150 cGy bid for NSCLC patients. A dose of 6500 cGy may be reasonable as it should theoretically give the same tumour control rate, less late complications, as well as a 10-15 days shorter treatment period. Many other ways of altering the dose-fractionation is also possible, e.g., 120 cGy bid followed by 150 bid in the same regimen." @default.
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• W2300975946 date "1992-12-01" @default.
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• W2300975946 title "Using Two Fractions per Day in Clinical Radiotherapy of Nasopharyngeal and Non-Small Cell Lung Cancer: A Tentative Isoeffect Dose Calculation Based on the LQ Model and Radiobiological and Clinical Inf" @default.
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