Matches in SemOpenAlex for { <https://semopenalex.org/work/W2301040956> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2301040956 endingPage "2099" @default.
- W2301040956 startingPage "2092" @default.
- W2301040956 abstract "OBJECTIVE To identify the self-antigens recognized by autoreactive T cells in labial salivary glands from patients with Sjogren's syndrome (SS). METHODS T cells lines were established from infiltrating T cells in the labial salivary glands from 6 patients with SS, using interleukin 2 and phytohemagglutinin. Bulk cultured T cells and T cell lines were examined for the proliferative response to recombinant Ro(SSA) 52 kDa and SSB proteins. The usage of T cell receptor (TCR) V beta and V alpha genes from Ro(SSA) 52kDa reactive T cells was analyzed by family polymerase chain reaction. The sequences of complementary determining region 3 of TCR V beta genes were also examined. RESULTS Three of 6 bulk cultured T cells and 4 of 16 T cell lines showed a significant proliferative response to Ro(SSA) 52 kDa protein. All T cell lines represented CD4+ alpha beta T cells by flow cytometry analysis. All 4 RO(SSA) 52 kDa reactive T cell lines utilized the V beta 2 gene and 3 lines used the V beta 13 gene, suggesting preferential usage of the V beta 2 and the V beta 13 genes in Ro(SSA) 52 kDa reactive T cells. Junctional sequences of TCR V beta genes from Ro(SSA) 52 kDa reactive T cell lines showed the conserved amino acid sequences in CDR3 region. CONCLUSION These findings support the notion that Ro(SSA) 52 kDa is a possible autoantigen recognized by autoreactive T cells and that limited epitope is present on the Ro(SSA) 52 kDa antigen." @default.
- W2301040956 created "2016-06-24" @default.
- W2301040956 creator A5006840501 @default.
- W2301040956 creator A5014468156 @default.
- W2301040956 creator A5019831592 @default.
- W2301040956 creator A5036181751 @default.
- W2301040956 creator A5038169485 @default.
- W2301040956 creator A5047829522 @default.
- W2301040956 creator A5057619326 @default.
- W2301040956 creator A5060464308 @default.
- W2301040956 creator A5063089880 @default.
- W2301040956 creator A5085431269 @default.
- W2301040956 date "1995-11-01" @default.
- W2301040956 modified "2023-09-23" @default.
- W2301040956 title "Identification of Ro(SSA) 52 kDa reactive T cells in labial salivary glands from patients with Sjögren's syndrome." @default.
- W2301040956 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8596150" @default.
- W2301040956 hasPublicationYear "1995" @default.
- W2301040956 type Work @default.
- W2301040956 sameAs 2301040956 @default.
- W2301040956 citedByCount "15" @default.
- W2301040956 countsByYear W23010409562013 @default.
- W2301040956 countsByYear W23010409562022 @default.
- W2301040956 crossrefType "journal-article" @default.
- W2301040956 hasAuthorship W2301040956A5006840501 @default.
- W2301040956 hasAuthorship W2301040956A5014468156 @default.
- W2301040956 hasAuthorship W2301040956A5019831592 @default.
- W2301040956 hasAuthorship W2301040956A5036181751 @default.
- W2301040956 hasAuthorship W2301040956A5038169485 @default.
- W2301040956 hasAuthorship W2301040956A5047829522 @default.
- W2301040956 hasAuthorship W2301040956A5057619326 @default.
- W2301040956 hasAuthorship W2301040956A5060464308 @default.
- W2301040956 hasAuthorship W2301040956A5063089880 @default.
- W2301040956 hasAuthorship W2301040956A5085431269 @default.
- W2301040956 hasConcept C147483822 @default.
- W2301040956 hasConcept C153911025 @default.
- W2301040956 hasConcept C19317047 @default.
- W2301040956 hasConcept C195616568 @default.
- W2301040956 hasConcept C199360897 @default.
- W2301040956 hasConcept C203014093 @default.
- W2301040956 hasConcept C2776090121 @default.
- W2301040956 hasConcept C2776174256 @default.
- W2301040956 hasConcept C2992881475 @default.
- W2301040956 hasConcept C41008148 @default.
- W2301040956 hasConcept C54355233 @default.
- W2301040956 hasConcept C553184892 @default.
- W2301040956 hasConcept C81885089 @default.
- W2301040956 hasConcept C86803240 @default.
- W2301040956 hasConcept C8891405 @default.
- W2301040956 hasConceptScore W2301040956C147483822 @default.
- W2301040956 hasConceptScore W2301040956C153911025 @default.
- W2301040956 hasConceptScore W2301040956C19317047 @default.
- W2301040956 hasConceptScore W2301040956C195616568 @default.
- W2301040956 hasConceptScore W2301040956C199360897 @default.
- W2301040956 hasConceptScore W2301040956C203014093 @default.
- W2301040956 hasConceptScore W2301040956C2776090121 @default.
- W2301040956 hasConceptScore W2301040956C2776174256 @default.
- W2301040956 hasConceptScore W2301040956C2992881475 @default.
- W2301040956 hasConceptScore W2301040956C41008148 @default.
- W2301040956 hasConceptScore W2301040956C54355233 @default.
- W2301040956 hasConceptScore W2301040956C553184892 @default.
- W2301040956 hasConceptScore W2301040956C81885089 @default.
- W2301040956 hasConceptScore W2301040956C86803240 @default.
- W2301040956 hasConceptScore W2301040956C8891405 @default.
- W2301040956 hasIssue "11" @default.
- W2301040956 hasLocation W23010409561 @default.
- W2301040956 hasOpenAccess W2301040956 @default.
- W2301040956 hasPrimaryLocation W23010409561 @default.
- W2301040956 hasRelatedWork W1969108300 @default.
- W2301040956 hasRelatedWork W1970151797 @default.
- W2301040956 hasRelatedWork W1974046006 @default.
- W2301040956 hasRelatedWork W1985018754 @default.
- W2301040956 hasRelatedWork W1994724205 @default.
- W2301040956 hasRelatedWork W2003484389 @default.
- W2301040956 hasRelatedWork W2004989086 @default.
- W2301040956 hasRelatedWork W2005621804 @default.
- W2301040956 hasRelatedWork W2010521626 @default.
- W2301040956 hasRelatedWork W2031004263 @default.
- W2301040956 hasRelatedWork W2046585466 @default.
- W2301040956 hasRelatedWork W2053840189 @default.
- W2301040956 hasRelatedWork W2055671309 @default.
- W2301040956 hasRelatedWork W2084043206 @default.
- W2301040956 hasRelatedWork W2117420131 @default.
- W2301040956 hasRelatedWork W2120773157 @default.
- W2301040956 hasRelatedWork W2129003247 @default.
- W2301040956 hasRelatedWork W2140582776 @default.
- W2301040956 hasRelatedWork W2151167261 @default.
- W2301040956 hasRelatedWork W2412761677 @default.
- W2301040956 hasVolume "22" @default.
- W2301040956 isParatext "false" @default.
- W2301040956 isRetracted "false" @default.
- W2301040956 magId "2301040956" @default.
- W2301040956 workType "article" @default.