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- W2301044499 abstract "The protective effect of 1-methyl-2-mercaptoimidazole (MI) on radiation sickness was investigated, using mice and rats. The effect of MI was compared with that of methyl-thiouracil (MT) under the same experimental con ditions. The administration of MI before irradiation caused marked prolongation of life span. Some favorable influence upon maintenance of the body weight also resulted. The administration of MI caused reduction and early recovery of leukopenia, particularly lymphopenia, following irradiation. In the pathological findings MI showed a marked protective effect against a loss of weight and the histological picture of the spleen. However, no definite effect was found on the changes of the liver and thyroid gland after irradiation. On the other hand the administration of MT caused no protective effect on radiation injuries. Both agents inhibited the thyroid function, with MT being more effective. (Absts. Japan. Med., 1: No. 7, 1960.)" @default.
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- W2301044499 date "1959-01-01" @default.
- W2301044499 modified "2023-09-26" @default.
- W2301044499 title "EXPERIMENTAL STUDY OF PROTECTIVE EFFECT OF 1-METHYL-2-MERCAPTOIMIDAZOLE ON RADIATION SICKNESS. I. A STUDY OF CHEMICAL PROTECTION AND RESTORATION AGAINST RADIATION INJURIES" @default.
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