Matches in SemOpenAlex for { <https://semopenalex.org/work/W2301058553> ?p ?o ?g. }
- W2301058553 abstract "Abstract Intercellular adhesion and electrical excitability are considered separate cellular properties. Studies of myelinated fibres, however, show that voltage-gated sodium channels (VGSCs) aggregate with cell adhesion molecules at discrete subcellular locations, such as the nodes of Ranvier. Demonstration of similar macromolecular organization in cardiac muscle is missing. Here we combine nanoscale-imaging (single-molecule localization microscopy; electron microscopy; and ‘angle view’ scanning patch clamp) with mathematical simulations to demonstrate distinct hubs at the cardiac intercalated disc, populated by clusters of the adhesion molecule N-cadherin and the VGSC Na V 1.5. We show that the N-cadherin-Na V 1.5 association is not random, that Na V 1.5 molecules in these clusters are major contributors to cardiac sodium current, and that loss of Na V 1.5 expression reduces intercellular adhesion strength. We speculate that adhesion/excitability nodes are key sites for crosstalk of the contractile and electrical molecular apparatus and may represent the structural substrate of cardiomyopathies in patients with mutations in molecules of the VGSC complex." @default.
- W2301058553 created "2016-06-24" @default.
- W2301058553 creator A5002659327 @default.
- W2301058553 creator A5008486598 @default.
- W2301058553 creator A5025650361 @default.
- W2301058553 creator A5051953374 @default.
- W2301058553 creator A5054022818 @default.
- W2301058553 creator A5055863077 @default.
- W2301058553 creator A5063431640 @default.
- W2301058553 creator A5065792746 @default.
- W2301058553 creator A5066635265 @default.
- W2301058553 creator A5078809987 @default.
- W2301058553 creator A5081602466 @default.
- W2301058553 creator A5086979289 @default.
- W2301058553 date "2016-01-20" @default.
- W2301058553 modified "2023-10-18" @default.
- W2301058553 title "Nanoscale visualization of functional adhesion/excitability nodes at the intercalated disc" @default.
- W2301058553 cites W1533368723 @default.
- W2301058553 cites W1966701241 @default.
- W2301058553 cites W1968196398 @default.
- W2301058553 cites W1975780081 @default.
- W2301058553 cites W1978545794 @default.
- W2301058553 cites W1978812569 @default.
- W2301058553 cites W1987637234 @default.
- W2301058553 cites W1990337343 @default.
- W2301058553 cites W1990649599 @default.
- W2301058553 cites W1990948522 @default.
- W2301058553 cites W1992058772 @default.
- W2301058553 cites W1994446230 @default.
- W2301058553 cites W2001892782 @default.
- W2301058553 cites W2003964447 @default.
- W2301058553 cites W2011549186 @default.
- W2301058553 cites W2023958353 @default.
- W2301058553 cites W2025173962 @default.
- W2301058553 cites W2028082846 @default.
- W2301058553 cites W2031426329 @default.
- W2301058553 cites W2042358404 @default.
- W2301058553 cites W2052783271 @default.
- W2301058553 cites W2055127006 @default.
- W2301058553 cites W2055700287 @default.
- W2301058553 cites W2060868528 @default.
- W2301058553 cites W2063741079 @default.
- W2301058553 cites W2066521860 @default.
- W2301058553 cites W2067066570 @default.
- W2301058553 cites W2068944023 @default.
- W2301058553 cites W2075746798 @default.
- W2301058553 cites W2077813193 @default.
- W2301058553 cites W2078939575 @default.
- W2301058553 cites W2079354464 @default.
- W2301058553 cites W2080923741 @default.
- W2301058553 cites W2086983465 @default.
- W2301058553 cites W2088319063 @default.
- W2301058553 cites W2090644365 @default.
- W2301058553 cites W2099540110 @default.
- W2301058553 cites W2102246439 @default.
- W2301058553 cites W2104415321 @default.
- W2301058553 cites W2104431345 @default.
- W2301058553 cites W2106326075 @default.
- W2301058553 cites W2107535926 @default.
- W2301058553 cites W2111394029 @default.
- W2301058553 cites W2111659160 @default.
- W2301058553 cites W2111880897 @default.
- W2301058553 cites W2113436414 @default.
- W2301058553 cites W2118896450 @default.
- W2301058553 cites W2120303052 @default.
- W2301058553 cites W2124733101 @default.
- W2301058553 cites W2132369818 @default.
- W2301058553 cites W2134740652 @default.
- W2301058553 cites W2135662719 @default.
- W2301058553 cites W2141083815 @default.
- W2301058553 cites W2142349419 @default.
- W2301058553 cites W2143454033 @default.
- W2301058553 cites W2145494795 @default.
- W2301058553 cites W2146807475 @default.
- W2301058553 cites W2147309367 @default.
- W2301058553 cites W2153540123 @default.
- W2301058553 cites W2154237611 @default.
- W2301058553 cites W2158580721 @default.
- W2301058553 cites W2165882991 @default.
- W2301058553 cites W2166330292 @default.
- W2301058553 cites W2166533036 @default.
- W2301058553 cites W2168493348 @default.
- W2301058553 doi "https://doi.org/10.1038/ncomms10342" @default.
- W2301058553 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4764909" @default.
- W2301058553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26899761" @default.
- W2301058553 hasPublicationYear "2016" @default.
- W2301058553 type Work @default.
- W2301058553 sameAs 2301058553 @default.
- W2301058553 citedByCount "72" @default.
- W2301058553 countsByYear W23010585532016 @default.
- W2301058553 countsByYear W23010585532017 @default.
- W2301058553 countsByYear W23010585532018 @default.
- W2301058553 countsByYear W23010585532019 @default.
- W2301058553 countsByYear W23010585532020 @default.
- W2301058553 countsByYear W23010585532021 @default.
- W2301058553 countsByYear W23010585532022 @default.
- W2301058553 countsByYear W23010585532023 @default.
- W2301058553 crossrefType "journal-article" @default.
- W2301058553 hasAuthorship W2301058553A5002659327 @default.
- W2301058553 hasAuthorship W2301058553A5008486598 @default.