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- W2301095588 abstract "The most upstream hypersensitive site (HS) of the β-globin locus control region (LCR) in humans (5′ HS 5) and chickens (5′ HS 4) can act as an insulating element in some gain of function assays and may demarcate a β-globin domain. We have mapped the most upstream HSs of the mouse β-globin LCR and sequenced this region. We find that mice have a region homologous to human 5′ HS 5 that is associated with a minor HS. In addition we map a unique HS upstream of 5′ HS 5 and refer to this novel site as mouse 5′ HS 6. We have also generated mice containing a targeted deletion of the region containing 5′ HS 5 and 6. We find that after excision of the selectable marker in vivo, deletion of 5′ HS 5 and 6 has a minimal effect on transcription and does not prevent formation of the remaining LCR HSs. Taken together these findings suggest that the most upstream HSs of the mouse β-globin LCR are not necessary for maintaining the β-globin locus in an active configuration or to protect it from a surrounding repressive chromatin environment." @default.
- W2301095588 created "2016-06-24" @default.
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- W2301095588 date "1998-12-01" @default.
- W2301095588 modified "2023-10-03" @default.
- W2301095588 title "Description and Targeted Deletion of 5′ Hypersensitive Site 5 and 6 of the Mouse β-Globin Locus Control Region" @default.
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- W2301095588 doi "https://doi.org/10.1182/blood.v92.11.4394.423k48_4394_4403" @default.
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