Matches in SemOpenAlex for { <https://semopenalex.org/work/W2301113670> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2301113670 endingPage "317" @default.
- W2301113670 startingPage "317" @default.
- W2301113670 abstract "Introduction: Telomerase is a ribonucleoprotein that adds TTA GGG nucleotide repeated into the ends of eukaryotic chromosomes to maintain their integrity. Most of the normal somatic cells do not express telomerase while telomerase is expressed in the vast majority of malignant tumor cells. Contradictory and limited data have been reported concerning the telomerase expression in soft-tissue sarcomas. The current study evaluates telomerase expression in a single histologic type of a high-grade soft-tissue sarcoma. Materials and Methods: A non-radioactive in situ hybridization (ISH) method was used to study the expression of the RNA component of human telomerase in 55 paraffin embedded archives tissue samples of patients who were diagnosed with synovial sarcoma, the diagnosis of which was based on morphologic, immunohistochemical, and cytogenetic characteristics. The intensity and distribution of telomerase RNA was scored by two different investigators. Intensity was graded as weak, moderate, or intensive. These parameters were further correlated to the oncologic status of the patient. Results: The majority of the investigated specimens demonstrated moderate to intensive telomerase RNA intensity with a diffuse distribution throughout the specimen. A positive correlation was found between telomerase intensity and progression of the underlying disease. Conclusions: Results of the current series suggest that upregulating of telomerase expression may play a role in the pathogenesis and biological activity of synovial sarcoma. This upregulation as detected by ISH assay may be a useful prognostic tool in the evaluation of these patients." @default.
- W2301113670 created "2016-06-24" @default.
- W2301113670 creator A5004631648 @default.
- W2301113670 creator A5009330949 @default.
- W2301113670 creator A5015822084 @default.
- W2301113670 creator A5024060614 @default.
- W2301113670 creator A5024279305 @default.
- W2301113670 creator A5033771770 @default.
- W2301113670 creator A5037950672 @default.
- W2301113670 creator A5075389657 @default.
- W2301113670 creator A5077579400 @default.
- W2301113670 creator A5085779285 @default.
- W2301113670 date "2002-11-01" @default.
- W2301113670 modified "2023-09-22" @default.
- W2301113670 title "TELOMERASE RNA EXPRESSION IN SYNOVIAL SARCOMA" @default.
- W2301113670 hasPublicationYear "2002" @default.
- W2301113670 type Work @default.
- W2301113670 sameAs 2301113670 @default.
- W2301113670 citedByCount "0" @default.
- W2301113670 crossrefType "journal-article" @default.
- W2301113670 hasAuthorship W2301113670A5004631648 @default.
- W2301113670 hasAuthorship W2301113670A5009330949 @default.
- W2301113670 hasAuthorship W2301113670A5015822084 @default.
- W2301113670 hasAuthorship W2301113670A5024060614 @default.
- W2301113670 hasAuthorship W2301113670A5024279305 @default.
- W2301113670 hasAuthorship W2301113670A5033771770 @default.
- W2301113670 hasAuthorship W2301113670A5037950672 @default.
- W2301113670 hasAuthorship W2301113670A5075389657 @default.
- W2301113670 hasAuthorship W2301113670A5077579400 @default.
- W2301113670 hasAuthorship W2301113670A5085779285 @default.
- W2301113670 hasConcept C104317684 @default.
- W2301113670 hasConcept C125593758 @default.
- W2301113670 hasConcept C142724271 @default.
- W2301113670 hasConcept C150194340 @default.
- W2301113670 hasConcept C177336024 @default.
- W2301113670 hasConcept C204232928 @default.
- W2301113670 hasConcept C2776910622 @default.
- W2301113670 hasConcept C2778256501 @default.
- W2301113670 hasConcept C2780942790 @default.
- W2301113670 hasConcept C34558173 @default.
- W2301113670 hasConcept C502942594 @default.
- W2301113670 hasConcept C54355233 @default.
- W2301113670 hasConcept C552990157 @default.
- W2301113670 hasConcept C67705224 @default.
- W2301113670 hasConcept C71924100 @default.
- W2301113670 hasConcept C75934600 @default.
- W2301113670 hasConcept C81439078 @default.
- W2301113670 hasConcept C86803240 @default.
- W2301113670 hasConcept C94581717 @default.
- W2301113670 hasConceptScore W2301113670C104317684 @default.
- W2301113670 hasConceptScore W2301113670C125593758 @default.
- W2301113670 hasConceptScore W2301113670C142724271 @default.
- W2301113670 hasConceptScore W2301113670C150194340 @default.
- W2301113670 hasConceptScore W2301113670C177336024 @default.
- W2301113670 hasConceptScore W2301113670C204232928 @default.
- W2301113670 hasConceptScore W2301113670C2776910622 @default.
- W2301113670 hasConceptScore W2301113670C2778256501 @default.
- W2301113670 hasConceptScore W2301113670C2780942790 @default.
- W2301113670 hasConceptScore W2301113670C34558173 @default.
- W2301113670 hasConceptScore W2301113670C502942594 @default.
- W2301113670 hasConceptScore W2301113670C54355233 @default.
- W2301113670 hasConceptScore W2301113670C552990157 @default.
- W2301113670 hasConceptScore W2301113670C67705224 @default.
- W2301113670 hasConceptScore W2301113670C71924100 @default.
- W2301113670 hasConceptScore W2301113670C75934600 @default.
- W2301113670 hasConceptScore W2301113670C81439078 @default.
- W2301113670 hasConceptScore W2301113670C86803240 @default.
- W2301113670 hasConceptScore W2301113670C94581717 @default.
- W2301113670 hasLocation W23011136701 @default.
- W2301113670 hasOpenAccess W2301113670 @default.
- W2301113670 hasPrimaryLocation W23011136701 @default.
- W2301113670 hasRelatedWork W1587322812 @default.
- W2301113670 hasRelatedWork W2011906885 @default.
- W2301113670 hasRelatedWork W2026291663 @default.
- W2301113670 hasRelatedWork W2038684575 @default.
- W2301113670 hasRelatedWork W2055225985 @default.
- W2301113670 hasRelatedWork W2087409144 @default.
- W2301113670 hasRelatedWork W2182748218 @default.
- W2301113670 hasRelatedWork W2348493810 @default.
- W2301113670 hasRelatedWork W2365343885 @default.
- W2301113670 hasRelatedWork W2378916930 @default.
- W2301113670 hasRelatedWork W2380335992 @default.
- W2301113670 hasRelatedWork W2384973476 @default.
- W2301113670 hasRelatedWork W2385628398 @default.
- W2301113670 hasRelatedWork W2393580821 @default.
- W2301113670 hasRelatedWork W2395633955 @default.
- W2301113670 hasRelatedWork W2398182056 @default.
- W2301113670 hasRelatedWork W2403399378 @default.
- W2301113670 hasRelatedWork W33083122 @default.
- W2301113670 hasRelatedWork W997377489 @default.
- W2301113670 hasRelatedWork W2123131889 @default.
- W2301113670 isParatext "false" @default.
- W2301113670 isRetracted "false" @default.
- W2301113670 magId "2301113670" @default.
- W2301113670 workType "article" @default.