Matches in SemOpenAlex for { <https://semopenalex.org/work/W2301114323> ?p ?o ?g. }
- W2301114323 abstract "Targeting CK2 for cancer therapy has proven effective in inhibiting tumor growth in several histology’s. The main goal of this study was to acquire pre-clinical data on a naturally occurring CK2-inhibitor (ellagic acid) in support of a human clinical trial. In vitro analysis included testing the spectrum of ellagic acid anti-cancer activity, defining the mode of growth inhibition in cancer cells and its impact on biochemical and molecular pathways. In vivo studies included determination of ellagic acid inhibitory effect in animal tumor models and toxicity analysis. We found that CK2 inhibition mediated by ellagic acid, was effective in inhibiting the growth of a wide spectrum of human cancer cells. These include breast cancer (MCF-7), kidney cancer (ACHN), colon adenocarcinoma (SW480), glioblastoma (U87), prostate cancer (DU-145), melanoma (WM164) and HPV -positive (HeLa) and -negative (C33A) cervical carcinomas. We used HeLa and C33A cell lines to determine EA mechanisms of action and impact on oncogenic, proliferative, and apoptotic pathways. Since CK2 controls over 300 target proteins involved in major biochemical and molecular pathways, we found that ellagic acid treatment was able to inhibit HPV oncogene expression, interrupt oncogenic pathways and induce anti-proliferative and pro-apoptotic pathways in HeLa cells. In" @default.
- W2301114323 created "2016-06-24" @default.
- W2301114323 creator A5015272778 @default.
- W2301114323 date "2012-01-01" @default.
- W2301114323 modified "2023-09-27" @default.
- W2301114323 title "Ellagic Acid-Mediated CK2 Inhibition;a Natural, Multifunctional Strategy to Trigger Cervical Cancer Cell Death in Vitro and in Vivo" @default.
- W2301114323 cites W122951635 @default.
- W2301114323 cites W1487134985 @default.
- W2301114323 cites W1510715774 @default.
- W2301114323 cites W1606900722 @default.
- W2301114323 cites W1745634660 @default.
- W2301114323 cites W1806932734 @default.
- W2301114323 cites W180900592 @default.
- W2301114323 cites W1872557913 @default.
- W2301114323 cites W1890251530 @default.
- W2301114323 cites W1964356985 @default.
- W2301114323 cites W1968329569 @default.
- W2301114323 cites W1971422523 @default.
- W2301114323 cites W1976457595 @default.
- W2301114323 cites W1976640978 @default.
- W2301114323 cites W1981387221 @default.
- W2301114323 cites W1981619037 @default.
- W2301114323 cites W1982179018 @default.
- W2301114323 cites W1987506447 @default.
- W2301114323 cites W1988769784 @default.
- W2301114323 cites W1990846609 @default.
- W2301114323 cites W1991633540 @default.
- W2301114323 cites W1992677777 @default.
- W2301114323 cites W1994835768 @default.
- W2301114323 cites W1995350271 @default.
- W2301114323 cites W1996165605 @default.
- W2301114323 cites W1997636770 @default.
- W2301114323 cites W1999124243 @default.
- W2301114323 cites W2002112794 @default.
- W2301114323 cites W2007001763 @default.
- W2301114323 cites W2007519824 @default.
- W2301114323 cites W2008757142 @default.
- W2301114323 cites W2009491438 @default.
- W2301114323 cites W2009729075 @default.
- W2301114323 cites W2010839009 @default.
- W2301114323 cites W2011123510 @default.
- W2301114323 cites W2011499737 @default.
- W2301114323 cites W2013983690 @default.
- W2301114323 cites W2014651582 @default.
- W2301114323 cites W2015123436 @default.
- W2301114323 cites W2016976833 @default.
- W2301114323 cites W2018646351 @default.
- W2301114323 cites W2020131060 @default.
- W2301114323 cites W2021152062 @default.
- W2301114323 cites W2023273217 @default.
- W2301114323 cites W2028040534 @default.
- W2301114323 cites W2029860792 @default.
- W2301114323 cites W2032531580 @default.
- W2301114323 cites W2033181253 @default.
- W2301114323 cites W2034757339 @default.
- W2301114323 cites W2039231543 @default.
- W2301114323 cites W2039382131 @default.
- W2301114323 cites W2044079387 @default.
- W2301114323 cites W2048736992 @default.
- W2301114323 cites W2051809501 @default.
- W2301114323 cites W2054374072 @default.
- W2301114323 cites W2058002757 @default.
- W2301114323 cites W2060480439 @default.
- W2301114323 cites W2064838744 @default.
- W2301114323 cites W2070244957 @default.
- W2301114323 cites W2075172158 @default.
- W2301114323 cites W2075679064 @default.
- W2301114323 cites W2076761848 @default.
- W2301114323 cites W2078267259 @default.
- W2301114323 cites W2081681244 @default.
- W2301114323 cites W2081723980 @default.
- W2301114323 cites W2084733813 @default.
- W2301114323 cites W2089963166 @default.
- W2301114323 cites W2091297863 @default.
- W2301114323 cites W2091616887 @default.
- W2301114323 cites W2093611899 @default.
- W2301114323 cites W2095440386 @default.
- W2301114323 cites W2096276671 @default.
- W2301114323 cites W2103234666 @default.
- W2301114323 cites W2103616303 @default.
- W2301114323 cites W2106787323 @default.
- W2301114323 cites W2108510669 @default.
- W2301114323 cites W2108805958 @default.
- W2301114323 cites W2109689528 @default.
- W2301114323 cites W2113795033 @default.
- W2301114323 cites W2117718012 @default.
- W2301114323 cites W2122140352 @default.
- W2301114323 cites W2123123035 @default.
- W2301114323 cites W2124052729 @default.
- W2301114323 cites W2129881449 @default.
- W2301114323 cites W2130066394 @default.
- W2301114323 cites W2133765716 @default.
- W2301114323 cites W2136741851 @default.
- W2301114323 cites W2138021651 @default.
- W2301114323 cites W2140433977 @default.
- W2301114323 cites W2141343893 @default.
- W2301114323 cites W2148990487 @default.
- W2301114323 cites W2150525034 @default.
- W2301114323 cites W2151501496 @default.
- W2301114323 cites W2155208683 @default.