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- W2301159346 abstract "In the present study, we investigated if a methanol extract of Cnidium officinale Makino (CO) can induce the apoptosis against human liver cancer HepG2 cell. HepG2 cells were treated with medium containing 0, 0.1, 0.25, 0.5, 0.75, 1 mg/ml of CO methanol extract. Cell proliferation assay was undertaken after 24hrs of incubation. Caspase-3 and p53 mRNA expression were measured by RT-PCR and protein expression by Western Blot. The antioxidant activity of CO was analyzed using DPPH assay. The HepG2 proliferation was inhibited by CO extract in dose dependent manner. The CO promoted activation of apoptotic caspase-3 and p53 genes. The CO showed free radical scavenging activity dose-dependently. The results suggested that CO-induced apoptosis of HepG2 cells may be mediated through the activation of apoptotic pathway involving caspase-3 and p53. In summary, CO may provide a new therapeutic option as a potential anticancer agent in the treatment of liver cancer." @default.
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- W2301159346 date "2010-04-01" @default.
- W2301159346 modified "2023-09-25" @default.
- W2301159346 title "Induction of Apoptosis by Methanol Extract of Cnidium officinale Makino through Activation of Caspase‐3 and p53 in Human Liver cancer HepG2 cell" @default.
- W2301159346 doi "https://doi.org/10.1096/fasebj.24.1_supplement.349.8" @default.
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